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Altered macrophage differentiation and immune dysfunction in tumor development.
Sica A, Bronte V. Sica A, et al. J Clin Invest. 2007 May;117(5):1155-66. doi: 10.1172/JCI31422. J Clin Invest. 2007. PMID: 17476345 Free PMC article. Review.
Tumors require a constant influx of myelomonocytic cells to support the angiogenesis and stroma remodeling needed for their growth. ...A complete understanding of the complex interplay between neoplastic and myelomonocytic cells might offer novel targets for therape …
Tumors require a constant influx of myelomonocytic cells to support the angiogenesis and stroma remodeling needed for their growth. . …
Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages.
Sica A, Saccani A, Bottazzi B, Polentarutti N, Vecchi A, van Damme J, Mantovani A. Sica A, et al. J Immunol. 2000 Jan 15;164(2):762-7. doi: 10.4049/jimmunol.164.2.762. J Immunol. 2000. PMID: 10623821
IL-12 is a central cytokine in the activation of inflammation and immunity and in the generation of Th1-type responses. Tumor-associated macrophages (TAM) from mouse and human tumors showed defective production of IL-12. ...
IL-12 is a central cytokine in the activation of inflammation and immunity and in the generation of Th1-type responses. Tumor-associa …
The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues.
Allavena P, Sica A, Vecchi A, Locati M, Sozzani S, Mantovani A. Allavena P, et al. Among authors: sica a. Immunol Rev. 2000 Oct;177:141-9. doi: 10.1034/j.1600-065x.2000.17714.x. Immunol Rev. 2000. PMID: 11138772 Review.
During maturation, DC undergo a profound and orderly rearrangement of their chemokine receptor repertoire. The chemokine receptor switch paradigm provides a conceptual framework for the complex migration of DC in vivo, including their recruitment and positioning in …
During maturation, DC undergo a profound and orderly rearrangement of their chemokine receptor repertoire. The chemokine receptor swi …
Tumor-associated macrophages: a molecular perspective.
Sica A, Saccani A, Mantovani A. Sica A, et al. Int Immunopharmacol. 2002 Jul;2(8):1045-54. doi: 10.1016/s1567-5769(02)00064-4. Int Immunopharmacol. 2002. PMID: 12349942 Review.
TAM represent a prominent component of the mononuclear leukocyte population of solid tumors, which displays an ambivalent relationship with tumors. ...
TAM represent a prominent component of the mononuclear leukocyte population of solid tumors, which displays an ambivalent relationshi …
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Mantovani A, et al. Among authors: sica a. Trends Immunol. 2002 Nov;23(11):549-55. doi: 10.1016/s1471-4906(02)02302-5. Trends Immunol. 2002. PMID: 12401408 Review.
Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states. Macrophages that infiltrate tumor tissues are driven by tumor-derived and T cell-derived cytokines to acquire a polarized M2 phenotype. These fun …
Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states. Macrophages …
Tumor-associated macrophages and dendritic cells as prototypic type II polarized myeloid populations.
Mantovani A, Schioppa T, Biswas SK, Marchesi F, Allavena P, Sica A. Mantovani A, et al. Among authors: sica a. Tumori. 2003 Sep-Oct;89(5):459-68. Tumori. 2003. PMID: 14870765 Review.
Fully polarized type I and type II (or alternatively activated) macrophages are the extremes of a continuum of functional states. Tumor-derived and T cell-derived cytokines stimulate tumor associated macrophages (TAM) to acquire a polarized type II phenotype. ...
Fully polarized type I and type II (or alternatively activated) macrophages are the extremes of a continuum of functional states. Tum …
Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
Mantovani A, Sozzani S, Locati M, Schioppa T, Saccani A, Allavena P, Sica A. Mantovani A, et al. Among authors: sica a. Novartis Found Symp. 2004;256:137-45; discussion 146-8, 259-69. Novartis Found Symp. 2004. PMID: 15027487 Review.
These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumour growth and progression....
These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subvers …
Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors.
Mantovani A, Allavena P, Sozzani S, Vecchi A, Locati M, Sica A. Mantovani A, et al. Among authors: sica a. Semin Cancer Biol. 2004 Jun;14(3):155-60. doi: 10.1016/j.semcancer.2003.10.001. Semin Cancer Biol. 2004. PMID: 15246050 Review.
Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. ...Chemokine-recruited and positioned tumor infiltrating leukocytes are a key comp …
Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory ci …
Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression.
Mantovani A, Allavena P, Sica A. Mantovani A, et al. Among authors: sica a. Eur J Cancer. 2004 Jul;40(11):1660-7. doi: 10.1016/j.ejca.2004.03.016. Eur J Cancer. 2004. PMID: 15251154 Review.
In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue remodelling and repair. As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote …
In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion o …
The chemokine system in diverse forms of macrophage activation and polarization.
Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. Mantovani A, et al. Among authors: sica a. Trends Immunol. 2004 Dec;25(12):677-86. doi: 10.1016/j.it.2004.09.015. Trends Immunol. 2004. PMID: 15530839 Review.
Here we review emerging key properties of different forms of macrophage activation and polarization (M1, M2a, M2b, M2c), which represent extremes of a continuum. ...
Here we review emerging key properties of different forms of macrophage activation and polarization (M1, M2a, M2b, M2c), which represent ext …
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