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Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability.
Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A. Colotta F, et al. Among authors: sica a. Carcinogenesis. 2009 Jul;30(7):1073-81. doi: 10.1093/carcin/bgp127. Epub 2009 May 25. Carcinogenesis. 2009. PMID: 19468060 Review.
In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark....
In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI …
Tumor-associated macrophages: a molecular perspective.
Sica A, Saccani A, Mantovani A. Sica A, et al. Int Immunopharmacol. 2002 Jul;2(8):1045-54. doi: 10.1016/s1567-5769(02)00064-4. Int Immunopharmacol. 2002. PMID: 12349942 Review.
TAM represent a prominent component of the mononuclear leukocyte population of solid tumors, which displays an ambivalent relationship with tumors. ...
TAM represent a prominent component of the mononuclear leukocyte population of solid tumors, which displays an ambivalent relationshi …
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Mantovani A, et al. Among authors: sica a. Trends Immunol. 2002 Nov;23(11):549-55. doi: 10.1016/s1471-4906(02)02302-5. Trends Immunol. 2002. PMID: 12401408 Review.
Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states. Macrophages that infiltrate tumor tissues are driven by tumor-derived and T cell-derived cytokines to acquire a polarized M2 phenotype. These fun …
Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states. Macrophages …
Tumor-associated macrophages and dendritic cells as prototypic type II polarized myeloid populations.
Mantovani A, Schioppa T, Biswas SK, Marchesi F, Allavena P, Sica A. Mantovani A, et al. Among authors: sica a. Tumori. 2003 Sep-Oct;89(5):459-68. Tumori. 2003. PMID: 14870765 Review.
Fully polarized type I and type II (or alternatively activated) macrophages are the extremes of a continuum of functional states. Tumor-derived and T cell-derived cytokines stimulate tumor associated macrophages (TAM) to acquire a polarized type II phenotype. ...
Fully polarized type I and type II (or alternatively activated) macrophages are the extremes of a continuum of functional states. Tum …
Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
Mantovani A, Sozzani S, Locati M, Schioppa T, Saccani A, Allavena P, Sica A. Mantovani A, et al. Among authors: sica a. Novartis Found Symp. 2004;256:137-45; discussion 146-8, 259-69. Novartis Found Symp. 2004. PMID: 15027487 Review.
These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumour growth and progression....
These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subvers …
Macrophage polarization comes of age.
Mantovani A, Sica A, Locati M. Mantovani A, et al. Among authors: sica a. Immunity. 2005 Oct;23(4):344-6. doi: 10.1016/j.immuni.2005.10.001. Immunity. 2005. PMID: 16226499 Review.
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy.
Sica A, Schioppa T, Mantovani A, Allavena P. Sica A, et al. Eur J Cancer. 2006 Apr;42(6):717-27. doi: 10.1016/j.ejca.2006.01.003. Epub 2006 Mar 7. Eur J Cancer. 2006. PMID: 16520032 Review.
The pro-tumoural role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage content of tumours and poor patient prognosis. Evidence is presented here supporting the view that TAM represent a unique and distinc …
The pro-tumoural role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage …
Role of tumor-associated macrophages in tumor progression and invasion.
Mantovani A, Schioppa T, Porta C, Allavena P, Sica A. Mantovani A, et al. Among authors: sica a. Cancer Metastasis Rev. 2006 Sep;25(3):315-22. doi: 10.1007/s10555-006-9001-7. Cancer Metastasis Rev. 2006. PMID: 16967326 Review.
The protumoral role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage content of tumors and poor patient prognosis and by evidence showing that long-term use of non-steroidal anti-inflammatory drugs reduces the r …
The protumoral role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage co …
p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance.
Saccani A, Schioppa T, Porta C, Biswas SK, Nebuloni M, Vago L, Bottazzi B, Colombo MP, Mantovani A, Sica A. Saccani A, et al. Among authors: sica a. Cancer Res. 2006 Dec 1;66(23):11432-40. doi: 10.1158/0008-5472.CAN-06-1867. Cancer Res. 2006. PMID: 17145890
Tumor-associated macrophages (TAM) are a major inflammatory infiltrate in tumors and a major component of the protumor function of inflammation. ...Here, we report that defective responsiveness of TAM from a murine fibrosarcoma and human ovarian carcinoma to …
Tumor-associated macrophages (TAM) are a major inflammatory infiltrate in tumors and a major component of the protumor functio …
Tumor promotion by tumor-associated macrophages.
Porta C, Subhra Kumar B, Larghi P, Rubino L, Mancino A, Sica A. Porta C, et al. Among authors: sica a. Adv Exp Med Biol. 2007;604:67-86. doi: 10.1007/978-0-387-69116-9_5. Adv Exp Med Biol. 2007. PMID: 17695721 Review.
Recent years have seen a renaissance of the inflammation-cancer connection stemming from different lines of work and leading to a generally accepted paradigm (Balkwill and Mantovani 2001; Mantovani et al. 2002; Coussens and Werb 2002; Balkwill et al. 2005). ...Chemo …
Recent years have seen a renaissance of the inflammation-cancer connection stemming from different lines of work and leading to a
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