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Macrophages, innate immunity and cancer: balance, tolerance, and diversity.
Mantovani A, Sica A. Mantovani A, et al. Curr Opin Immunol. 2010 Apr;22(2):231-7. doi: 10.1016/j.coi.2010.01.009. Epub 2010 Feb 9. Curr Opin Immunol. 2010. PMID: 20144856 Review.
Smouldering inflammation is a component of the tumor microenvironment and represents the 7(th) hallmark of cancer. Tumor-associated macrophages (TAM) have served as a paradigm for cancer promoting inflammation. Tumor-associated macrophages orchestrate various aspect …
Smouldering inflammation is a component of the tumor microenvironment and represents the 7(th) hallmark of cancer. Tumor-associated m …
IL-1 transcriptionally activates the neutrophil chemotactic factor/IL-8 gene in endothelial cells.
Sica A, Matsushima K, Van Damme J, Wang JM, Polentarutti N, Dejana E, Colotta F, Mantovani A. Sica A, et al. Immunology. 1990 Apr;69(4):548-53. Immunology. 1990. PMID: 2185985 Free PMC article.
The present study was designed to define the capacity of human endothelial cells (HEC) to produce a monocyte-derived neutrophil chemotactic factor (provisionally termed IL-8). IL-8 is a polypeptide chemotactic for neutrophils originally identified in the culture sup …
The present study was designed to define the capacity of human endothelial cells (HEC) to produce a monocyte-derived neutrophil chemo …
Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma.
Sica A, Saccani A, Bottazzi B, Bernasconi S, Allavena P, Gaetano B, Fei F, LaRosa G, Scotton C, Balkwill F, Mantovani A. Sica A, et al. J Immunol. 2000 Jan 15;164(2):733-8. doi: 10.4049/jimmunol.164.2.733. J Immunol. 2000. PMID: 10623817
CCR2 gene expression and chemotactic response to MCP-1 were decreased to a lesser extent in blood monocytes from cancer patients. ...Receptor inhibition may serve as a mechanism to arrest and retain recruited macrophages and to prevent chemokine scavenging by mononu …
CCR2 gene expression and chemotactic response to MCP-1 were decreased to a lesser extent in blood monocytes from cancer patients. ... …
Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages.
Sica A, Saccani A, Bottazzi B, Polentarutti N, Vecchi A, van Damme J, Mantovani A. Sica A, et al. J Immunol. 2000 Jan 15;164(2):762-7. doi: 10.4049/jimmunol.164.2.762. J Immunol. 2000. PMID: 10623821
IL-12 is a central cytokine in the activation of inflammation and immunity and in the generation of Th1-type responses. Tumor-associated macrophages (TAM) from mouse and human tumors showed defective production of IL-12. ...
IL-12 is a central cytokine in the activation of inflammation and immunity and in the generation of Th1-type responses. Tumor-associa …
Tumor-associated macrophages: a molecular perspective.
Sica A, Saccani A, Mantovani A. Sica A, et al. Int Immunopharmacol. 2002 Jul;2(8):1045-54. doi: 10.1016/s1567-5769(02)00064-4. Int Immunopharmacol. 2002. PMID: 12349942 Review.
TAM represent a prominent component of the mononuclear leukocyte population of solid tumors, which displays an ambivalent relationship with tumors. ...
TAM represent a prominent component of the mononuclear leukocyte population of solid tumors, which displays an ambivalent relationshi …
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Mantovani A, et al. Trends Immunol. 2002 Nov;23(11):549-55. doi: 10.1016/s1471-4906(02)02302-5. Trends Immunol. 2002. PMID: 12401408 Review.
Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states. Macrophages that infiltrate tumor tissues are driven by tumor-derived and T cell-derived cytokines to acquire a polarized M2 phenotype. These fun …
Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states. Macrophages …
Tumor-associated macrophages and dendritic cells as prototypic type II polarized myeloid populations.
Mantovani A, Schioppa T, Biswas SK, Marchesi F, Allavena P, Sica A. Mantovani A, et al. Tumori. 2003 Sep-Oct;89(5):459-68. Tumori. 2003. PMID: 14870765 Review.
Fully polarized type I and type II (or alternatively activated) macrophages are the extremes of a continuum of functional states. Tumor-derived and T cell-derived cytokines stimulate tumor associated macrophages (TAM) to acquire a polarized type II phenotype. ...
Fully polarized type I and type II (or alternatively activated) macrophages are the extremes of a continuum of functional states. Tum …
Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
Mantovani A, Sozzani S, Locati M, Schioppa T, Saccani A, Allavena P, Sica A. Mantovani A, et al. Novartis Found Symp. 2004;256:137-45; discussion 146-8, 259-69. Novartis Found Symp. 2004. PMID: 15027487 Review.
These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumour growth and progression....
These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subvers …
Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors.
Mantovani A, Allavena P, Sozzani S, Vecchi A, Locati M, Sica A. Mantovani A, et al. Semin Cancer Biol. 2004 Jun;14(3):155-60. doi: 10.1016/j.semcancer.2003.10.001. Semin Cancer Biol. 2004. PMID: 15246050 Review.
Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. ...Chemokine-recruited and positioned tumor infiltrating leukocytes are a key comp …
Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory ci …
Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression.
Mantovani A, Allavena P, Sica A. Mantovani A, et al. Eur J Cancer. 2004 Jul;40(11):1660-7. doi: 10.1016/j.ejca.2004.03.016. Eur J Cancer. 2004. PMID: 15251154 Review.
In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue remodelling and repair. As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote …
In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion o …
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