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Macrophage plasticity and polarization: in vivo veritas.
Sica A, Mantovani A. Sica A, et al. J Clin Invest. 2012 Mar;122(3):787-95. doi: 10.1172/JCI59643. Epub 2012 Mar 1. J Clin Invest. 2012. PMID: 22378047 Free PMC article. Review.
In response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes of a continuum in a universe of activation states. ...The identification of mechanisms and molecu …
In response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages undergo M1 (classical) or M2 (alternative) activati …
Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma.
Sica A, Saccani A, Bottazzi B, Bernasconi S, Allavena P, Gaetano B, Fei F, LaRosa G, Scotton C, Balkwill F, Mantovani A. Sica A, et al. J Immunol. 2000 Jan 15;164(2):733-8. doi: 10.4049/jimmunol.164.2.733. J Immunol. 2000. PMID: 10623817
CCR2 gene expression and chemotactic response to MCP-1 were decreased to a lesser extent in blood monocytes from cancer patients. ...Receptor inhibition may serve as a mechanism to arrest and retain recruited macrophages and to prevent chemokine scavenging by mononu …
CCR2 gene expression and chemotactic response to MCP-1 were decreased to a lesser extent in blood monocytes from cancer patients. ... …
Tumor-associated macrophages: a molecular perspective.
Sica A, Saccani A, Mantovani A. Sica A, et al. Int Immunopharmacol. 2002 Jul;2(8):1045-54. doi: 10.1016/s1567-5769(02)00064-4. Int Immunopharmacol. 2002. PMID: 12349942 Review.
TAM represent a prominent component of the mononuclear leukocyte population of solid tumors, which displays an ambivalent relationship with tumors. ...
TAM represent a prominent component of the mononuclear leukocyte population of solid tumors, which displays an ambivalent relationshi …
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Mantovani A, et al. Trends Immunol. 2002 Nov;23(11):549-55. doi: 10.1016/s1471-4906(02)02302-5. Trends Immunol. 2002. PMID: 12401408 Review.
Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states. Macrophages that infiltrate tumor tissues are driven by tumor-derived and T cell-derived cytokines to acquire a polarized M2 phenotype. These fun …
Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states. Macrophages …
Tumor-associated macrophages and dendritic cells as prototypic type II polarized myeloid populations.
Mantovani A, Schioppa T, Biswas SK, Marchesi F, Allavena P, Sica A. Mantovani A, et al. Tumori. 2003 Sep-Oct;89(5):459-68. Tumori. 2003. PMID: 14870765 Review.
Fully polarized type I and type II (or alternatively activated) macrophages are the extremes of a continuum of functional states. Tumor-derived and T cell-derived cytokines stimulate tumor associated macrophages (TAM) to acquire a polarized type II phenotype. ...
Fully polarized type I and type II (or alternatively activated) macrophages are the extremes of a continuum of functional states. Tum …
Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
Mantovani A, Sozzani S, Locati M, Schioppa T, Saccani A, Allavena P, Sica A. Mantovani A, et al. Novartis Found Symp. 2004;256:137-45; discussion 146-8, 259-69. Novartis Found Symp. 2004. PMID: 15027487 Review.
These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumour growth and progression....
These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subvers …
The chemokine system in diverse forms of macrophage activation and polarization.
Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. Mantovani A, et al. Trends Immunol. 2004 Dec;25(12):677-86. doi: 10.1016/j.it.2004.09.015. Trends Immunol. 2004. PMID: 15530839 Review.
Here we review emerging key properties of different forms of macrophage activation and polarization (M1, M2a, M2b, M2c), which represent extremes of a continuum. ...
Here we review emerging key properties of different forms of macrophage activation and polarization (M1, M2a, M2b, M2c), which represent ext …
Macrophage polarization comes of age.
Mantovani A, Sica A, Locati M. Mantovani A, et al. Immunity. 2005 Oct;23(4):344-6. doi: 10.1016/j.immuni.2005.10.001. Immunity. 2005. PMID: 16226499 Review.
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy.
Sica A, Schioppa T, Mantovani A, Allavena P. Sica A, et al. Eur J Cancer. 2006 Apr;42(6):717-27. doi: 10.1016/j.ejca.2006.01.003. Epub 2006 Mar 7. Eur J Cancer. 2006. PMID: 16520032 Review.
The pro-tumoural role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage content of tumours and poor patient prognosis. Evidence is presented here supporting the view that TAM represent a unique and distinc …
The pro-tumoural role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage …
Role of tumor-associated macrophages in tumor progression and invasion.
Mantovani A, Schioppa T, Porta C, Allavena P, Sica A. Mantovani A, et al. Cancer Metastasis Rev. 2006 Sep;25(3):315-22. doi: 10.1007/s10555-006-9001-7. Cancer Metastasis Rev. 2006. PMID: 16967326 Review.
The protumoral role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage content of tumors and poor patient prognosis and by evidence showing that long-term use of non-steroidal anti-inflammatory drugs reduces the r …
The protumoral role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage co …
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