A novel pyrrole alkaloid from the fruit peels of Strychnos nux-blanda

Nat Prod Res. 2017 Jan;31(2):149-154. doi: 10.1080/14786419.2016.1222388. Epub 2016 Aug 22.

Abstract

A novel pyrrole alkaloid, strychnuxin (1), along with five known compounds (2-6) was isolated from the fruit peels of Strychnos nux-blanda. The structures of all the isolated compounds (1-6) were fully characterised using spectroscopic data, as well as comparison with the previous literature data. Moreover, all isolated compounds were assessed for their α-glucosidase and acetylcholinesterase inhibitory activities.

Keywords: Loganiaceae; Strychnos nux-blanda; antiacetylcholinesterase activity; pyrrole alkaloid; α-glucosidase inhibitory activity.

MeSH terms

  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / pharmacology
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Fruit / chemistry*
  • Plant Extracts / chemistry
  • Pyrroles / chemistry*
  • Pyrroles / pharmacology*
  • Seeds / chemistry
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Ultraviolet
  • Strychnos / chemistry*
  • Thailand
  • alpha-Glucosidases

Substances

  • Cholinesterase Inhibitors
  • Enzyme Inhibitors
  • Plant Extracts
  • Pyrroles
  • strychnuxin
  • alpha-Glucosidases