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Effect of deficiency of the double-stranded RNA-dependent protein kinase, PKR, on antiviral resistance in the presence or absence of ribonuclease L: HSV-1 replication is particularly sensitive to deficiency of the major IFN-mediated enzymes.
Khabar KS, Dhalla M, Siddiqui Y, Zhou A, Al-Ahdal MN, Der SD, Silverman RH, Williams BR. Khabar KS, et al. J Interferon Cytokine Res. 2000 Jul;20(7):653-9. doi: 10.1089/107999000414835. J Interferon Cytokine Res. 2000. PMID: 10926208
RNase L mediates transient control of the interferon response through modulation of the double-stranded RNA-dependent protein kinase PKR.
Khabar KS, Siddiqui YM, al-Zoghaibi F, al-Haj L, Dhalla M, Zhou A, Dong B, Whitmore M, Paranjape J, Al-Ahdal MN, Al-Mohanna F, Williams BR, Silverman RH. Khabar KS, et al. Among authors: siddiqui ym. J Biol Chem. 2003 May 30;278(22):20124-32. doi: 10.1074/jbc.M208766200. Epub 2003 Feb 11. J Biol Chem. 2003. PMID: 12582177 Free article.
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