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The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy.
Sidenius N, Blasi F. Sidenius N, et al. Cancer Metastasis Rev. 2003 Jun-Sep;22(2-3):205-22. doi: 10.1023/a:1023099415940. Cancer Metastasis Rev. 2003. PMID: 12784997 Review.
Urokinase links plasminogen activation and cell adhesion by cleavage of the RGD motif in vitronectin.
De Lorenzi V, Sarra Ferraris GM, Madsen JB, Lupia M, Andreasen PA, Sidenius N. De Lorenzi V, et al. Among authors: sidenius n. EMBO Rep. 2016 Jul;17(7):982-98. doi: 10.15252/embr.201541681. Epub 2016 May 17. EMBO Rep. 2016. PMID: 27189837 Free PMC article.
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells.
van Veen M, Matas-Rico E, van de Wetering K, Leyton-Puig D, Kedziora KM, De Lorenzi V, Stijf-Bultsma Y, van den Broek B, Jalink K, Sidenius N, Perrakis A, Moolenaar WH. van Veen M, et al. Among authors: sidenius n. Elife. 2017 Aug 29;6:e23649. doi: 10.7554/eLife.23649. Elife. 2017. PMID: 28849762 Free PMC article.
Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation.
Zhao B, Gandhi S, Yuan C, Luo Z, Li R, Gårdsvoll H, de Lorenzi V, Sidenius N, Huang M, Ploug M. Zhao B, et al. Among authors: sidenius n. J Mol Biol. 2015 Mar 27;427(6 Pt B):1389-1403. doi: 10.1016/j.jmb.2015.01.022. Epub 2015 Feb 7. J Mol Biol. 2015. PMID: 25659907
Urokinase plasminogen activator receptor: a functional integrator of extracellular proteolysis, cell adhesion, and signal transduction.
Ferraris GM, Sidenius N. Ferraris GM, et al. Among authors: sidenius n. Semin Thromb Hemost. 2013 Jun;39(4):347-55. doi: 10.1055/s-0033-1334485. Epub 2013 Mar 26. Semin Thromb Hemost. 2013. PMID: 23532573 Review.
Direct evidence of the importance of vitronectin and its interaction with the urokinase receptor in tumor growth.
Pirazzoli V, Ferraris GM, Sidenius N. Pirazzoli V, et al. Among authors: sidenius n. Blood. 2013 Mar 21;121(12):2316-23. doi: 10.1182/blood-2012-08-451187. Epub 2013 Jan 17. Blood. 2013. PMID: 23327926
Urinary levels of urokinase-type plasminogen activator and its receptor in the detection of bladder carcinoma.
Sier CF, Blasi F, Sidenius N. Sier CF, et al. Among authors: sidenius n. Cancer. 2003 Nov 1;98(9):1995; author reply 1996. doi: 10.1002/cncr.11751. Cancer. 2003. PMID: 14584084 No abstract available.
Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilization.
Selleri C, Montuori N, Ricci P, Visconte V, Carriero MV, Sidenius N, Serio B, Blasi F, Rotoli B, Rossi G, Ragno P. Selleri C, et al. Among authors: sidenius n. Blood. 2005 Mar 1;105(5):2198-205. doi: 10.1182/blood-2004-06-2424. Epub 2004 Oct 19. Blood. 2005. PMID: 15494432
Increased soluble urokinase plasminogen activator receptor (suPAR) levels in neovascular age-related macular degeneration: a role for inflammation in the pathogenesis of the disease?
Scotti F, Milani P, Setaccioli M, Maestroni S, Sidenius N, De Lorenzi V, Massacesi A, Bergamini F, Zerbini G. Scotti F, et al. Among authors: sidenius n. Graefes Arch Clin Exp Ophthalmol. 2019 May;257(5):899-903. doi: 10.1007/s00417-018-04230-w. Epub 2019 Jan 7. Graefes Arch Clin Exp Ophthalmol. 2019. PMID: 30617582
The interaction between uPAR and vitronectin triggers ligand-independent adhesion signalling by integrins.
Ferraris GM, Schulte C, Buttiglione V, De Lorenzi V, Piontini A, Galluzzi M, Podestà A, Madsen CD, Sidenius N. Ferraris GM, et al. Among authors: sidenius n. EMBO J. 2014 Nov 3;33(21):2458-72. doi: 10.15252/embj.201387611. Epub 2014 Aug 28. EMBO J. 2014. PMID: 25168639 Free PMC article.
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