Siegmund HU - Search Results

1

Contribution of rivaroxaban to the international normalized ratio when switching to warfarin for anticoagulation as determined by simulation studies.

Siegmund HU, Burghaus R, Kubitza D, Coboeken K. Siegmund HU, et al. Br J Clin Pharmacol. 2015 Jun;79(6):959-66. doi: 10.1111/bcp.12571. Br J Clin Pharmacol. 2015. PMID: 25510952 Free PMC article.

2

Development of a paediatric population-based model of the pharmacokinetics of rivaroxaban.

Willmann S, Becker C, Burghaus R, Coboeken K, Edginton A, Lippert J, Siegmund HU, Thelen K, Mück W. Willmann S, et al. Among authors: siegmund hu. Clin Pharmacokinet. 2014 Jan;53(1):89-102. doi: 10.1007/s40262-013-0090-5. Clin Pharmacokinet. 2014. PMID: 23912563 Free PMC article. Clinical Trial.

3

Comment on model-based meta-analysis to evaluate optimal doses of direct oral factor Xa inhibitors in atrial fibrillation patients.

Willmann S, Zhang L, Mayer H, Siegmund HU, Tanigawa T, Kaneko M, Peters G, Weitz JI, Berkowitz SD, Burghaus R. Willmann S, et al. Among authors: siegmund hu. Blood Adv. 2018 Nov 27;2(22):3193-3195. doi: 10.1182/bloodadvances.2018027078. Blood Adv. 2018. PMID: 30482761 Free PMC article. No abstract available.

4

Evaluation of the efficacy and safety of rivaroxaban using a computer model for blood coagulation.

Burghaus R, Coboeken K, Gaub T, Kuepfer L, Sensse A, Siegmund HU, Weiss W, Mueck W, Lippert J. Burghaus R, et al. Among authors: siegmund hu. PLoS One. 2011 Apr 22;6(4):e17626. doi: 10.1371/journal.pone.0017626. PLoS One. 2011. PMID: 21526168 Free PMC article.

5

Computational investigation of potential dosing schedules for a switch of medication from warfarin to rivaroxaban-an oral, direct Factor Xa inhibitor.

Burghaus R, Coboeken K, Gaub T, Niederalt C, Sensse A, Siegmund HU, Weiss W, Mueck W, Tanigawa T, Lippert J. Burghaus R, et al. Among authors: siegmund hu. Front Physiol. 2014 Nov 7;5:417. doi: 10.3389/fphys.2014.00417. eCollection 2014. Front Physiol. 2014. PMID: 25426077 Free PMC article.

6

A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.

Eissing T, Kuepfer L, Becker C, Block M, Coboeken K, Gaub T, Goerlitz L, Jaeger J, Loosen R, Ludewig B, Meyer M, Niederalt C, Sevestre M, Siegmund HU, Solodenko J, Thelen K, Telle U, Weiss W, Wendl T, Willmann S, Lippert J. Eissing T, et al. Among authors: siegmund hu. Front Physiol. 2011 Feb 24;2:4. doi: 10.3389/fphys.2011.00004. eCollection 2011. Front Physiol. 2011. PMID: 21483730 Free PMC article.

7

A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim.

Niederalt C, Kuepfer L, Solodenko J, Eissing T, Siegmund HU, Block M, Willmann S, Lippert J. Niederalt C, et al. Among authors: siegmund hu. J Pharmacokinet Pharmacodyn. 2018 Apr;45(2):235-257. doi: 10.1007/s10928-017-9559-4. Epub 2017 Dec 12. J Pharmacokinet Pharmacodyn. 2018. PMID: 29234936 Free PMC article.

8

Förster energy transfer in ultrathin polymer layers as a basis for biosensors.

Völker M, Siegmund HU. Völker M, et al. Among authors: siegmund hu. EXS. 1997;80:175-91. doi: 10.1007/978-3-0348-9043-4_12. EXS. 1997. PMID: 9002213

9

A mechanistic, model-based approach to safety assessment in clinical development.

Lippert J, Brosch M, von Kampen O, Meyer M, Siegmund HU, Schafmayer C, Becker T, Laffert B, Görlitz L, Schreiber S, Neuvonen PJ, Niemi M, Hampe J, Kuepfer L. Lippert J, et al. Among authors: siegmund hu. CPT Pharmacometrics Syst Pharmacol. 2012 Nov 7;1(11):e13. doi: 10.1038/psp.2012.14. CPT Pharmacometrics Syst Pharmacol. 2012. PMID: 23835795 Free PMC article.

10

Dolichyl phosphate-dependent glycosyltransferases utilize truncated cofactors.

Jaenicke L, van Leyen K, Siegmund HU. Jaenicke L, et al. Among authors: siegmund hu. Biol Chem Hoppe Seyler. 1991 Nov;372(11):1021-6. doi: 10.1515/bchm3.1991.372.2.1021. Biol Chem Hoppe Seyler. 1991. PMID: 1724374

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