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The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ.
Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M, Piccolo S. Chang L, et al. Among authors: sigismondo g. Nature. 2018 Nov;563(7730):265-269. doi: 10.1038/s41586-018-0658-1. Epub 2018 Oct 31. Nature. 2018. PMID: 30401838 Free PMC article.
Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4.
Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, Quaranta E, Di Biagio D, Sigismondo G, Guzzardo V, Lejeune P, Haendler B, Krijgsveld J, Fassan M, Bicciato S, Cordenonsi M, Piccolo S. Zanconato F, et al. Among authors: sigismondo g. Nat Med. 2018 Oct;24(10):1599-1610. doi: 10.1038/s41591-018-0158-8. Epub 2018 Sep 17. Nat Med. 2018. PMID: 30224758 Free PMC article.
Protease-resistant streptavidin for interaction proteomics.
Rafiee MR, Sigismondo G, Kalxdorf M, Förster L, Brügger B, Béthune J, Krijgsveld J. Rafiee MR, et al. Among authors: sigismondo g. Mol Syst Biol. 2020 May;16(5):e9370. doi: 10.15252/msb.20199370. Mol Syst Biol. 2020. PMID: 32400114 Free PMC article.
Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection.
Selkrig J, Li N, Hausmann A, Mangan MSJ, Zietek M, Mateus A, Bobonis J, Sueki A, Imamura H, El Debs B, Sigismondo G, Florea BI, Overkleeft HS, Kopitar-Jerala N, Turk B, Beltrao P, Savitski MM, Latz E, Hardt WD, Krijgsveld J, Typas A. Selkrig J, et al. Among authors: sigismondo g. Nat Microbiol. 2020 Sep;5(9):1119-1133. doi: 10.1038/s41564-020-0736-7. Epub 2020 Jun 8. Nat Microbiol. 2020. PMID: 32514074 Free PMC article.
ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition.
Bakr A, Hey J, Sigismondo G, Liu CS, Sadik A, Goyal A, Cross A, Iyer RL, Müller P, Trauernicht M, Breuer K, Lutsik P, Opitz CA, Krijgsveld J, Weichenhan D, Plass C, Popanda O, Schmezer P. Bakr A, et al. Among authors: sigismondo g. Nucleic Acids Res. 2021 Nov 18;49(20):11666-11689. doi: 10.1093/nar/gkab964. Nucleic Acids Res. 2021. PMID: 34718742 Free PMC article.
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