Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

49 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
Simple and cost-effective hardware and software for functional brain mapping using intrinsic optical signal imaging.
Harrison TC, Sigler A, Murphy TH. Harrison TC, et al. J Neurosci Methods. 2009 Sep 15;182(2):211-8. doi: 10.1016/j.jneumeth.2009.06.021. Epub 2009 Jun 24. J Neurosci Methods. 2009. PMID: 19559049
We describe a simple and low-cost system for intrinsic optical signal (IOS) imaging using stable LED light sources, basic microscopes, and commonly available CCD cameras. IOS imaging measures activity-dependent changes in the light reflectance of brain tissue, and can be p …
We describe a simple and low-cost system for intrinsic optical signal (IOS) imaging using stable LED light sources, basic microscopes …
Automated and quantitative image analysis of ischemic dendritic blebbing using in vivo 2-photon microscopy data.
Chen S, Tran S, Sigler A, Murphy TH. Chen S, et al. J Neurosci Methods. 2011 Feb 15;195(2):222-31. doi: 10.1016/j.jneumeth.2010.12.018. Epub 2010 Dec 22. J Neurosci Methods. 2011. PMID: 21184780
Ischemia induces a 'blebbing' of dendrites, a structural alteration where dendrites take on a 'beads on a string' appearance. ...By comparing acquired images during ischemia and reperfusion to a pre-ischemia reference image, our automated approa …
Ischemia induces a 'blebbing' of dendrites, a structural alteration where dendrites take on a 'beads on a string …
In vivo 2-photon imaging of fine structure in the rodent brain: before, during, and after stroke.
Sigler A, Murphy TH. Sigler A, et al. Stroke. 2010 Oct;41(10 Suppl):S117-23. doi: 10.1161/STROKEAHA.110.594648. Stroke. 2010. PMID: 20876484 Review.
Surprisingly, restoration of blood flow during reperfusion was associated with a return of relatively normal structure. Over longer time scales, 2-photon imaging revealed elevated rates of synaptogenesis within peri-infarct tissues recovering from stroke. ...
Surprisingly, restoration of blood flow during reperfusion was associated with a return of relatively normal structure. Over longer t …
Imaging rapid redistribution of sensory-evoked depolarization through existing cortical pathways after targeted stroke in mice.
Sigler A, Mohajerani MH, Murphy TH. Sigler A, et al. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11759-64. doi: 10.1073/pnas.0812695106. Epub 2009 Jul 1. Proc Natl Acad Sci U S A. 2009. PMID: 19571005 Free PMC article.
After stroke to a subset of the forelimb somatosensory cortex map, function was lost in ischemic areas within the forelimb map center, but maintained in regions 200-500 microm blood flow deficits indicating the size of a perfused, but nonfunctional, penumbra. In man …
After stroke to a subset of the forelimb somatosensory cortex map, function was lost in ischemic areas within the forelimb map center …
Hardware and methodology for targeting single brain arterioles for photothrombotic stroke on an upright microscope.
Sigler A, Goroshkov A, Murphy TH. Sigler A, et al. J Neurosci Methods. 2008 May 15;170(1):35-44. doi: 10.1016/j.jneumeth.2007.12.015. Epub 2008 Jan 5. J Neurosci Methods. 2008. PMID: 18289696
To induce targeted strokes we describe a simple adaptation of a commercial upright Olympus BX51WI microscope, permitting light from a 532 nm laser to be directed into the back aperture of a high numerical aperture fluorescence objective. The system inv …
To induce targeted strokes we describe a simple adaptation of a commercial upright Olympus BX51WI microscope, permitting light …
Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming.
Varoqueaux F, Sigler A, Rhee JS, Brose N, Enk C, Reim K, Rosenmund C. Varoqueaux F, et al. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):9037-42. doi: 10.1073/pnas.122623799. Epub 2002 Jun 17. Proc Natl Acad Sci U S A. 2002. PMID: 12070347 Free PMC article.
However, a small subpopulation of synapses in any given glutamatergic nerve cell as well as all gamma-aminobutyratergic (GABAergic) synapses are largely independent of Munc13-1. ...We conclude that Munc13-mediated vesicle priming is not a transmitter specific phenom …
However, a small subpopulation of synapses in any given glutamatergic nerve cell as well as all gamma-aminobutyratergic (GABAergic) s …
An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size.
Wojcik SM, Rhee JS, Herzog E, Sigler A, Jahn R, Takamori S, Brose N, Rosenmund C. Wojcik SM, et al. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7158-63. doi: 10.1073/pnas.0401764101. Epub 2004 Apr 21. Proc Natl Acad Sci U S A. 2004. PMID: 15103023 Free PMC article.
Glutamatergic neurotransmission is drastically reduced in neurons from VGLUT1-deficient mice, with a specific reduction in quantal size. ...
Glutamatergic neurotransmission is drastically reduced in neurons from VGLUT1-deficient mice, with a specific reduction in quantal si …
Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.
Sigler A, Oh WC, Imig C, Altas B, Kawabe H, Cooper BH, Kwon HB, Rhee JS, Brose N. Sigler A, et al. Neuron. 2017 Apr 19;94(2):304-311.e4. doi: 10.1016/j.neuron.2017.03.029. Neuron. 2017. PMID: 28426965 Free PMC article.
Dendritic spines are the major transmitter reception compartments of glutamatergic synapses in most principal neurons of the mammalian brain and play a key role in the function of nerve cell circuits. ...
Dendritic spines are the major transmitter reception compartments of glutamatergic synapses in most principal neurons of the mammalian brain …
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, Toselli M, Brose N, Parenti M, Rhee J. Ripamonti S, et al. Elife. 2017 Feb 23;6:e22466. doi: 10.7554/eLife.22466. Elife. 2017. PMID: 28231043 Free PMC article.
These results indicate that oxytocin controls the development of hippocampal excitatory neurons and contributes to the maintenance of a physiological excitation/inhibition balance, whose disruption can cause neurobehavioral disturbances....
These results indicate that oxytocin controls the development of hippocampal excitatory neurons and contributes to the maintenance of a
CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.
Jockusch WJ, Speidel D, Sigler A, Sørensen JB, Varoqueaux F, Rhee JS, Brose N. Jockusch WJ, et al. Cell. 2007 Nov 16;131(4):796-808. doi: 10.1016/j.cell.2007.11.002. Cell. 2007. PMID: 18022372
CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, which causes a selective impairment of fast phasic transmitter release. ...Our findings demonstrate that CAPS proteins generate and maintain a highly fusion competent synaptic vesicle …
CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, which causes a selective impairment of fast phasic …
49 results
Jump to page
Feedback