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Signal transduction and functional selectivity of F15599, a preferential post-synaptic 5-HT1A receptor agonist.
Newman-Tancredi A, Martel JC, Assié MB, Buritova J, Lauressergues E, Cosi C, Heusler P, Bruins Slot L, Colpaert FC, Vacher B, Cussac D. Newman-Tancredi A, et al. Br J Pharmacol. 2009 Jan;156(2):338-53. doi: 10.1111/j.1476-5381.2008.00001.x. Epub 2009 Jan 12. Br J Pharmacol. 2009. PMID: 19154445 Free PMC article.
We describe the signal transduction profile of F15599, a novel 5-HT(1A) receptor agonist. ...CONCLUSIONS AND IMPLICATIONS: F15599 showed a distinctive activation profiles for 5-HT(1A) receptor-mediated signalling path …
We describe the signal transduction profile of F15599, a novel 5-HT(1A) receptor agonist. ...CONCL …
F15599, a preferential post-synaptic 5-HT1A receptor agonist: activity in models of cognition in comparison with reference 5-HT1A receptor agonists.
Depoortère R, Auclair AL, Bardin L, Colpaert FC, Vacher B, Newman-Tancredi A. Depoortère R, et al. Eur Neuropsychopharmacol. 2010 Sep;20(9):641-54. doi: 10.1016/j.euroneuro.2010.04.005. Epub 2010 May 21. Eur Neuropsychopharmacol. 2010. PMID: 20488670
We assessed the activity of F15599, a selective and high efficacy 5-HT(1A) agonist that preferentially activates post- versus pre-synaptic receptors, in rat cognition/memory models. ...This suggests that preferential activat …
We assessed the activity of F15599, a selective and high efficacy 5-HT(1A) agonist that preferentially ac …
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