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Signal transduction and functional selectivity of F15599, a preferential post-synaptic 5-HT1A receptor agonist.
Newman-Tancredi A, Martel JC, Assié MB, Buritova J, Lauressergues E, Cosi C, Heusler P, Bruins Slot L, Colpaert FC, Vacher B, Cussac D. Newman-Tancredi A, et al. Br J Pharmacol. 2009 Jan;156(2):338-53. doi: 10.1111/j.1476-5381.2008.00001.x. Epub 2009 Jan 12. Br J Pharmacol. 2009. PMID: 19154445 Free PMC article.
We describe the signal transduction profile of F15599, a novel 5-HT(1A) receptor agonist. EXPERIMENTAL APPROACH: F15599 was compared with a chemical congener, F13714, and with (+)8-OH-DPAT in models of signal transduction in …
We describe the signal transduction profile of F15599, a novel 5-HT(1A) receptor agonist. EXPERIMENTAL AP …
F15599, a preferential post-synaptic 5-HT1A receptor agonist: activity in models of cognition in comparison with reference 5-HT1A receptor agonists.
Depoortère R, Auclair AL, Bardin L, Colpaert FC, Vacher B, Newman-Tancredi A. Depoortère R, et al. Eur Neuropsychopharmacol. 2010 Sep;20(9):641-54. doi: 10.1016/j.euroneuro.2010.04.005. Epub 2010 May 21. Eur Neuropsychopharmacol. 2010. PMID: 20488670
We assessed the activity of F15599, a selective and high efficacy 5-HT(1A) agonist that preferentially activates post- versus pre-synaptic receptors, in rat cognition/memory models. ...This suggests that preferential activation of post- …
We assessed the activity of F15599, a selective and high efficacy 5-HT(1A) agonist that preferentially activates …
Pharmacological MRI to investigate the functional selectivity of 5-HT(1A) receptor biased agonists.
Vidal B, Bolbos R, Redouté J, Langlois JB, Costes N, Newman-Tancredi A, Zimmer L. Vidal B, et al. Neuropharmacology. 2020 Aug 1;172:107867. doi: 10.1016/j.neuropharm.2019.107867. Epub 2019 Nov 26. Neuropharmacology. 2020. PMID: 31783063
The emerging concept of "biased agonism" denotes the phenomenon whereby agonists can preferentially direct receptor signalling to specific intracellular responses among the different transduction pathways, thus potentially avoiding side effects and imp …
The emerging concept of "biased agonism" denotes the phenomenon whereby agonists can preferentially direct receptor sig …