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Resveratrol as an anticancer nutrient: molecular basis, open questions and promises.
Signorelli P, Ghidoni R. Signorelli P, et al. J Nutr Biochem. 2005 Aug;16(8):449-66. doi: 10.1016/j.jnutbio.2005.01.017. J Nutr Biochem. 2005. PMID: 16043028 Review.
Resveratrol acts as a selective estrogen receptor modulator (SERM) and regulates proteins involved in DNA synthesis and cell cycle, such as p(53) and Rb/E2F, cyclins, cyclin-dependent kinases (CDKs) and their inhibitors. ...Moreover, resveratrol affects the expression and …
Resveratrol acts as a selective estrogen receptor modulator (SERM) and regulates proteins involved in DNA synthesis and cell cycle, such as …
Breast cancer and sphingolipid signalling.
Signorelli P, Ghidoni R. Signorelli P, et al. J Dairy Res. 2005;72 Spec No:5-13. doi: 10.1017/s0022029905001238. J Dairy Res. 2005. PMID: 16180715 Review. No abstract available.
Inhibition of human breast cancer cell growth and enzymatic activity by a fermented nutraceutical: an in vitro and in vivo study.
Marotta F, Yadav H, Pathak S, Minelli E, Signorelli P, Lorenzetti A, Marandola P. Marotta F, et al. Ann N Y Acad Sci. 2009 Feb;1155:273-7. doi: 10.1111/j.1749-6632.2008.03684.x. Ann N Y Acad Sci. 2009. PMID: 19250216

In vitro, it appeared a dose-dependent decrease of cell viability (5-57%) in MK group in both cell lines (P < 0.001, plateau: 30 microg/ml), decreased beta-galactosidase activity, enhanced apoptosis, and inversely increased Bax/Bcl2 ratio (P < 0.01) with an up

In vitro, it appeared a dose-dependent decrease of cell viability (5-57%) in MK group in both cell lines (P < 0.001, plateau: 30 m

Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells.
Signorelli P, Munoz-Olaya JM, Gagliostro V, Casas J, Ghidoni R, Fabriàs G. Signorelli P, et al. Cancer Lett. 2009 Sep 18;282(2):238-43. doi: 10.1016/j.canlet.2009.03.020. Epub 2009 Apr 25. Cancer Lett. 2009. PMID: 19394759
Naphthalene-fused (α-alkoxycarbonyl)methylene-γ-butyrolactones: antiproliferative activity and binding to bovine serum albumin and DNA.
Rajabi M, Khalilzadeh MA, Tavakolinia F, Signorelli P, Ghidoni R, Santaniello E. Rajabi M, et al. DNA Cell Biol. 2012 May;31(5):783-9. doi: 10.1089/dna.2011.1433. Epub 2011 Nov 10. DNA Cell Biol. 2012. PMID: 22074127
Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy.
Gagliostro V, Casas J, Caretti A, Abad JL, Tagliavacca L, Ghidoni R, Fabrias G, Signorelli P. Gagliostro V, et al. Int J Biochem Cell Biol. 2012 Dec;44(12):2135-43. doi: 10.1016/j.biocel.2012.08.025. Epub 2012 Sep 7. Int J Biochem Cell Biol. 2012. PMID: 22960157
Natural grape extracts regulate colon cancer cells malignancy.
Signorelli P, Fabiani C, Brizzolari A, Paroni R, Casas J, Fabriàs G, Rossi D, Ghidoni R, Caretti A. Signorelli P, et al. Nutr Cancer. 2015;67(3):494-503. doi: 10.1080/01635581.2015.1004591. Epub 2015 Feb 23. Nutr Cancer. 2015. PMID: 25705818
An Innovative Lipidomic Workflow to Investigate the Lipid Profile in a Cystic Fibrosis Cell Line.
Dei Cas M, Zulueta A, Mingione A, Caretti A, Ghidoni R, Signorelli P, Paroni R. Dei Cas M, et al. Among authors: signorelli p. Cells. 2020 May 12;9(5):1197. doi: 10.3390/cells9051197. Cells. 2020. PMID: 32408521 Free PMC article.
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