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HIF-1 as a target for drug development.
Giaccia A, Siim BG, Johnson RS. Giaccia A, et al. Among authors: siim bg. Nat Rev Drug Discov. 2003 Oct;2(10):803-11. doi: 10.1038/nrd1199. Nat Rev Drug Discov. 2003. PMID: 14526383 Review.
Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin.
Kovacs MS, Hocking DJ, Evans JW, Siim BG, Wouters BG, Brown JM. Kovacs MS, et al. Among authors: siim bg. Br J Cancer. 1999 Jun;80(8):1245-51. doi: 10.1038/sj.bjc.6690492. Br J Cancer. 1999. PMID: 10376978 Free PMC article.
Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia.
Siim BG, Menke DR, Dorie MJ, Brown JM. Siim BG, et al. Cancer Res. 1997 Jul 15;57(14):2922-8. Cancer Res. 1997. PMID: 9230202
Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity.
Elwell JH, Siim BG, Evans JW, Brown JM. Elwell JH, et al. Among authors: siim bg. Biochem Pharmacol. 1997 Jul 15;54(2):249-57. doi: 10.1016/s0006-2952(97)00171-8. Biochem Pharmacol. 1997. PMID: 9271329
Hypoxia-Specific Cytotoxins in Cancer Therapy.
Brown JM, Siim BG. Brown JM, et al. Among authors: siim bg. Semin Radiat Oncol. 1996 Jan;6(1):22-36. doi: 10.1053/SRAO0060022. Semin Radiat Oncol. 1996. PMID: 10717159
Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro.
Siim BG, van Zijl PL, Brown JM. Siim BG, et al. Br J Cancer. 1996 Apr;73(8):952-60. doi: 10.1038/bjc.1996.187. Br J Cancer. 1996. PMID: 8611431 Free PMC article.
Efficient redox cycling of nitroquinoline bioreductive drugs due to aerobic nitroreduction in Chinese hamster cells.
Siim BG, Wilson WR. Siim BG, et al. Biochem Pharmacol. 1995 Jun 29;50(1):75-82. doi: 10.1016/0006-2952(95)00112-d. Biochem Pharmacol. 1995. PMID: 7605348
Nitro reduction as an electronic switch for bioreductive drug activation.
Siim BG, Denny WA, Wilson WR. Siim BG, et al. Oncol Res. 1997;9(6-7):357-69. Oncol Res. 1997. PMID: 9406242 Review.
Hypoxia-selective antitumor agents. 15. Modification of rate of nitroreduction and extent of lysosomal uptake by polysubstitution of 4-(alkylamino)-5-nitroquinoline bioreductive drugs.
Siim BG, Atwell GJ, Anderson RF, Wardman P, Pullen SM, Wilson WR, Denny WA. Siim BG, et al. J Med Chem. 1997 Apr 25;40(9):1381-90. doi: 10.1021/jm9607865. J Med Chem. 1997. PMID: 9135035
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