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Silexan, an essential oil from flowers of Lavandula angustifolia, is not recognized as benzodiazepine-like in rats trained to discriminate a diazepam cue.
Silenieks LB, Koch E, Higgins GA. Silenieks LB, et al. Phytomedicine. 2013 Jan 15;20(2):172-7. doi: 10.1016/j.phymed.2012.10.004. Epub 2012 Nov 30. Phytomedicine. 2013. PMID: 23207249
The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to feeding behavior and impulse control.
Higgins GA, Silenieks LB, Rossmann A, Rizos Z, Noble K, Soko AD, Fletcher PJ. Higgins GA, et al. Among authors: silenieks lb. Neuropsychopharmacology. 2012 Apr;37(5):1177-91. doi: 10.1038/npp.2011.303. Epub 2011 Dec 21. Neuropsychopharmacology. 2012. PMID: 22189292 Free PMC article.
Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement.
Fletcher PJ, Rizos Z, Noble K, Soko AD, Silenieks LB, LĂȘ AD, Higgins GA. Fletcher PJ, et al. Among authors: silenieks lb. Neuropharmacology. 2012 Jun;62(7):2288-98. doi: 10.1016/j.neuropharm.2012.01.023. Epub 2012 Feb 8. Neuropharmacology. 2012. PMID: 22342986
Enduring attentional deficits in rats treated with a peripheral nerve injury.
Higgins GA, Silenieks LB, Van Niekerk A, Desnoyer J, Patrick A, Lau W, Thevarkunnel S. Higgins GA, et al. Among authors: silenieks lb. Behav Brain Res. 2015 Jun 1;286:347-55. doi: 10.1016/j.bbr.2015.02.050. Epub 2015 Mar 5. Behav Brain Res. 2015. PMID: 25746510
Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT2C receptor agonists.
Higgins GA, Silenieks LB, Altherr EB, MacMillan C, Fletcher PJ, Pratt WE. Higgins GA, et al. Among authors: silenieks lb. Psychopharmacology (Berl). 2016 Jul;233(14):2841-56. doi: 10.1007/s00213-016-4329-3. Epub 2016 May 30. Psychopharmacology (Berl). 2016. PMID: 27241709
Preclinical evidence for combining the 5-HT2C receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence.
Fletcher PJ, Li Z, Silenieks LB, MacMillan C, DeLannoy I, Higgins GA. Fletcher PJ, et al. Among authors: silenieks lb. Addict Biol. 2019 May;24(3):376-387. doi: 10.1111/adb.12602. Epub 2018 Mar 2. Addict Biol. 2019. PMID: 29498158
Effects of 5-HT2C receptor modulation and the NA reuptake inhibitor atomoxetine in tests of compulsive and impulsive behaviour.
Higgins GA, Brown M, St John J, MacMillan C, Silenieks LB, Thevarkunnel S. Higgins GA, et al. Among authors: silenieks lb. Neuropharmacology. 2020 Jun 15;170:108064. doi: 10.1016/j.neuropharm.2020.108064. Epub 2020 Mar 25. Neuropharmacology. 2020. PMID: 32222404
Characterization of Amphetamine, Methylphenidate, Nicotine, and Atomoxetine on Measures of Attention, Impulsive Action, and Motivation in the Rat: Implications for Translational Research.
Higgins GA, Silenieks LB, MacMillan C, Thevarkunnel S, Parachikova AI, Mombereau C, Lindgren H, Bastlund JF. Higgins GA, et al. Among authors: silenieks lb. Front Pharmacol. 2020 Apr 24;11:427. doi: 10.3389/fphar.2020.00427. eCollection 2020. Front Pharmacol. 2020. PMID: 32390829 Free PMC article.
Characterization of the 5-HT2C receptor agonist lorcaserin on efficacy and safety measures in a rat model of diet-induced obesity.
Higgins GA, Desnoyer J, Van Niekerk A, Silenieks LB, Lau W, Thevarkunnel S, Izhakova J, DeLannoy IA, Fletcher PJ, DeLay J, Dobson H. Higgins GA, et al. Among authors: silenieks lb. Pharmacol Res Perspect. 2015 Feb;3(1):e00084. doi: 10.1002/prp2.84. Epub 2014 Nov 7. Pharmacol Res Perspect. 2015. PMID: 25692009 Free PMC article.
Enhanced attention and impulsive action following NMDA receptor GluN2B-selective antagonist pretreatment.
Higgins GA, Silenieks LB, MacMillan C, Sevo J, Zeeb FD, Thevarkunnel S. Higgins GA, et al. Among authors: silenieks lb. Behav Brain Res. 2016 Sep 15;311:1-14. doi: 10.1016/j.bbr.2016.05.025. Epub 2016 May 11. Behav Brain Res. 2016. PMID: 27180168
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