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The Anticancer Properties of Silibinin: Its Molecular Mechanism and Therapeutic Effect in Breast Cancer.
Binienda A, Ziolkowska S, Pluciennik E. Binienda A, et al. Anticancer Agents Med Chem. 2020;20(15):1787-1796. doi: 10.2174/1871520620666191220142741. Anticancer Agents Med Chem. 2020. PMID: 31858905 Review.
It has an antioxidant and anti-inflammatory effect on hepatocytes and is known to inhibit cell proliferation, induce apoptosis, and curb angiogenesis. ...CONCLUSION: Summarizing, SB inhibits proliferation, induces apoptosis, and re …
It has an antioxidant and anti-inflammatory effect on hepatocytes and is known to inhibit cell proliferation, induce …
Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells.
Sharma G, Singh RP, Chan DC, Agarwal R. Sharma G, et al. Anticancer Res. 2003 May-Jun;23(3B):2649-55. Anticancer Res. 2003. PMID: 12894553
MATERIALS AND METHODS: We used small cell lung carcinoma cells (SCLC) SHP-77 and non-small cell lung carcinoma cells (NSCLC) A-549, analyzing cell growth inhibition and death with Trypan blue excl …
MATERIALS AND METHODS: We used small cell lung carcinoma cells (SCLC) SHP-77 and non-small cell lung …
Silibinin inhibits fibronectin induced motility, invasiveness and survival in human prostate carcinoma PC3 cells via targeting integrin signaling.
Deep G, Kumar R, Jain AK, Agarwal C, Agarwal R. Deep G, et al. Mutat Res. 2014 Oct;768:35-46. doi: 10.1016/j.mrfmmm.2014.05.002. Mutat Res. 2014. PMID: 25285031 Free PMC article.
Accordingly, here we examined silibinin effect on advanced human PCA PC3 cells' interaction with extracellular matrix component fibronectin. ...Silibinin also decreased the fibronectin-induced cell proliferation and motility but significa …
Accordingly, here we examined silibinin effect on advanced human PCA PC3 cells' interaction with extracellular matrix c …
Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma.
Li J, Li B, Xu WW, Chan KW, Guan XY, Qin YR, Lee NP, Chan KT, Law S, Tsao SW, Cheung AL. Li J, et al. Expert Opin Ther Targets. 2016;20(1):7-18. doi: 10.1517/14728222.2016.1121236. Epub 2015 Dec 15. Expert Opin Ther Targets. 2016. PMID: 26568207
RESEARCH DESIGN AND METHODS: We determined the expression status and role of AMPK in esophageal squamous cell carcinoma (ESCC) and investigated whether silibinin, a nontoxic natural product, could activate AMPK to inhibit ESCC development. ...We …
RESEARCH DESIGN AND METHODS: We determined the expression status and role of AMPK in esophageal squamous cell carcinoma (ESCC) …
Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance.
Singh RP, Mallikarjuna GU, Sharma G, Dhanalakshmi S, Tyagi AK, Chan DC, Agarwal C, Agarwal R. Singh RP, et al. Clin Cancer Res. 2004 Dec 15;10(24):8641-7. doi: 10.1158/1078-0432.CCR-04-1435. Clin Cancer Res. 2004. PMID: 15623648

Pharmacologic dose of silibinin (60 mumol/L) achieved in animal study was biologically effective (P < 0.01 to 0.001, growth inhibition and apoptosis) in vitro in A549 cell culture together with an increased efficacy (P < 0.05 to 0.001) in

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Pharmacologic dose of silibinin (60 mumol/L) achieved in animal study was biologically effective (P < 0.01 to 0.001, growth

…
Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model.
Raina K, Rajamanickam S, Singh RP, Deep G, Chittezhath M, Agarwal R. Raina K, et al. Cancer Res. 2008 Aug 15;68(16):6822-30. doi: 10.1158/0008-5472.CAN-08-1332. Cancer Res. 2008. PMID: 18701508 Free PMC article.
During early stages of prostate tumor development, silibinin mediated its efficacy mostly via antiproliferative mechanisms. Feeding of silibinin to animals burdened with higher stages of prostate tumor significantly decreased tumor grade via antiproliferative …
During early stages of prostate tumor development, silibinin mediated its efficacy mostly via antiproliferative mechanisms. Fe …
Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis.
Singh RP, Tyagi AK, Zhao J, Agarwal R. Singh RP, et al. Carcinogenesis. 2002 Mar;23(3):499-510. doi: 10.1093/carcin/23.3.499. Carcinogenesis. 2002. PMID: 11895866
Silibinin treatment of cells in culture at 12.5, 25 (plasma level) and 50 microM doses resulted in 30-74% (P < 0.01-0.001) growth inhibition and 7-42% death of A431 cells in a dose- and time-dependent manner; apoptosis was ident …
Silibinin treatment of cells in culture at 12.5, 25 (plasma level) and 50 microM doses resulted in 30-74% (P < 0.01-0.001) …