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IAPs, RINGs and ubiquitylation.
Vaux DL, Silke J. Vaux DL, et al. Among authors: silke j. Nat Rev Mol Cell Biol. 2005 Apr;6(4):287-97. doi: 10.1038/nrm1621. Nat Rev Mol Cell Biol. 2005. PMID: 15803136 Review.
NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2.
Diessenbacher P, Hupe M, Sprick MR, Kerstan A, Geserick P, Haas TL, Wachter T, Neumann M, Walczak H, Silke J, Leverkus M. Diessenbacher P, et al. Among authors: silke j. J Invest Dermatol. 2008 May;128(5):1134-47. doi: 10.1038/sj.jid.5701141. Epub 2007 Nov 8. J Invest Dermatol. 2008. PMID: 17989734
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.
Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, Benetatos CA, Chunduru SK, Condon SM, McKinlay M, Brink R, Leverkus M, Tergaonkar V, Schneider P, Callus BA, Koentgen F, Vaux DL, Silke J. Vince JE, et al. Among authors: silke j. Cell. 2007 Nov 16;131(4):682-93. doi: 10.1016/j.cell.2007.10.037. Cell. 2007. PMID: 18022363
Another facet of ubiquitylation: death.
Wong WW, Silke J. Wong WW, et al. Among authors: silke j. J Mol Cell Biol. 2009 Dec;1(2):80-1. doi: 10.1093/jmcb/mjp019. Epub 2009 Sep 30. J Mol Cell Biol. 2009. PMID: 19797318
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.
Vince JE, Pantaki D, Feltham R, Mace PD, Cordier SM, Schmukle AC, Davidson AJ, Callus BA, Wong WW, Gentle IE, Carter H, Lee EF, Walczak H, Day CL, Vaux DL, Silke J. Vince JE, et al. Among authors: silke j. J Biol Chem. 2009 Dec 18;284(51):35906-15. doi: 10.1074/jbc.M109.072256. J Biol Chem. 2009. PMID: 19815541 Free PMC article.
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