Silva Elipe MV - Search Results

1

In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes.

Agrawal AK, Hop CE, Pang J, Silva Elipe MV, Desai RC, Leung KH, Franklin RB. Agrawal AK, et al. Among authors: silva elipe mv. J Pharm Biomed Anal. 2005 Feb 23;37(2):351-8. doi: 10.1016/j.jpba.2004.10.036. J Pharm Biomed Anal. 2005. PMID: 15708677

2

Metabolism of MK-0524, a prostaglandin D2 receptor 1 antagonist, in microsomes and hepatocytes from preclinical species and humans.

Dean BJ, Chang S, Silva Elipe MV, Xia YQ, Braun M, Soli E, Zhao Y, Franklin RB, Karanam B. Dean BJ, et al. Among authors: silva elipe mv. Drug Metab Dispos. 2007 Feb;35(2):283-92. doi: 10.1124/dmd.106.011551. Epub 2006 Nov 28. Drug Metab Dispos. 2007. PMID: 17132765

3

In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium and quinone type metabolites.

Zhang Z, Chen Q, Li Y, Doss GA, Dean BJ, Ngui JS, Silva Elipe M, Kim S, Wu JY, Dininno F, Hammond ML, Stearns RA, Evans DC, Baillie TA, Tang W. Zhang Z, et al. Chem Res Toxicol. 2005 Apr;18(4):675-85. doi: 10.1021/tx0496789. Chem Res Toxicol. 2005. PMID: 15833027

4

Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins.

Singh R, Silva Elipe MV, Pearson PG, Arison BH, Wong BK, White R, Yu X, Burgey CS, Lin JH, Baillie TA. Singh R, et al. Among authors: silva elipe mv. Chem Res Toxicol. 2003 Feb;16(2):198-207. doi: 10.1021/tx025635l. Chem Res Toxicol. 2003. PMID: 12588191

5

Bioactivation of the 3-amino-6-chloropyrazinone ring in a thrombin inhibitor leads to novel dihydro-imidazole and imidazolidine derivatives: structures and mechanism using 13C-labels, mass spectrometry, and NMR.

Subramanian R, Lin CC, Ho JZ, Pitzenberger SM, Silva-Elipe MV, Gibson CR, Braun MP, Yu X, Yergey JL, Singh R. Subramanian R, et al. Among authors: silva elipe mv. Drug Metab Dispos. 2003 Nov;31(11):1437-47. doi: 10.1124/dmd.31.11.1437. Drug Metab Dispos. 2003. PMID: 14570777

6

A novel lipid hydroperoxide-derived modification to arginine.

Oe T, Lee SH, Silva Elipe MV, Arison BH, Blair IA. Oe T, et al. Among authors: silva elipe mv. Chem Res Toxicol. 2003 Dec;16(12):1598-605. doi: 10.1021/tx034178l. Chem Res Toxicol. 2003. PMID: 14680374

7

Characterization of 2'-deoxycytidine adducts derived from 4-oxo-2-nonenal, a novel lipid peroxidation product.

Pollack M, Oe T, Lee SH, Silva Elipe MV, Arison BH, Blair IA. Pollack M, et al. Among authors: silva elipe mv. Chem Res Toxicol. 2003 Jul;16(7):893-900. doi: 10.1021/tx030009p. Chem Res Toxicol. 2003. PMID: 12870892

8

Unexpected formation of etheno-2'-deoxyguanosine adducts from 5(S)-hydroperoxyeicosatetraenoic acid: evidence for a bis-hydroperoxide intermediate.

Jian W, Lee SH, Arora JS, Silva Elipe MV, Blair IA. Jian W, et al. Among authors: silva elipe mv. Chem Res Toxicol. 2005 Mar;18(3):599-610. doi: 10.1021/tx049693d. Chem Res Toxicol. 2005. PMID: 15777099

9

Dioxododecenoic acid: a lipid hydroperoxide-derived bifunctional electrophile responsible for etheno DNA adduct formation.

Lee SH, Silva Elipe MV, Arora JS, Blair IA. Lee SH, et al. Among authors: silva elipe mv. Chem Res Toxicol. 2005 Mar;18(3):566-78. doi: 10.1021/tx049716o. Chem Res Toxicol. 2005. PMID: 15777096

10

Isolation and structure elucidation of unexpected in-process impurities during tetrazole ring formation of an investigational drug substance.

Silva Elipe MV, Yoo C, Xia F, Simiens J, Crossley K, Huckins JR, Guo HX, Tedrow J, Wong-Moon K. Silva Elipe MV, et al. Magn Reson Chem. 2017 Apr;55(4):253-262. doi: 10.1002/mrc.4413. Epub 2016 Feb 3. Magn Reson Chem. 2017. PMID: 26841697

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