Silva J - Search Results

1

LC-ESI-MS/MS quantification of 4β-hydroxycholesterol and cholesterol in plasma samples of limited volume.

Xu Y, Yuan Y, Smith L, Edom R, Weng N, Mamidi R, Silva J, Evans DC, Lim HK. Xu Y, et al. Among authors: silva j. J Pharm Biomed Anal. 2013 Nov;85:145-54. doi: 10.1016/j.jpba.2013.07.016. Epub 2013 Jul 25. J Pharm Biomed Anal. 2013. PMID: 23948760

2

A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.

Lim HK, Chen J, Cook K, Sensenhauser C, Silva J, Evans DC. Lim HK, et al. Among authors: silva j. Rapid Commun Mass Spectrom. 2008 Apr;22(8):1295-311. doi: 10.1002/rcm.3504. Rapid Commun Mass Spectrom. 2008. PMID: 18383206

3

Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.

Lim HK, Chen J, Sensenhauser C, Cook K, Preston R, Thomas T, Shook B, Jackson PF, Rassnick S, Rhodes K, Gopaul V, Salter R, Silva J, Evans DC. Lim HK, et al. Among authors: silva j. Chem Res Toxicol. 2011 Jul 18;24(7):1012-30. doi: 10.1021/tx1004437. Epub 2011 Jun 28. Chem Res Toxicol. 2011. PMID: 21667953

4

Free radical metabolism of raloxifene in human liver microsomes.

Lim HK, Yang M, Lam W, Xu F, Chen J, Xu Y, Shetty HU, Yang K, Silva J, Evans DC. Lim HK, et al. Among authors: silva j. Xenobiotica. 2012 Aug;42(8):737-47. doi: 10.3109/00498254.2012.662306. Xenobiotica. 2012. PMID: 22375838

5

De-risking bio-therapeutics for possible drug interactions using cryopreserved human hepatocytes.

Dallas S, Sensenhauser C, Batheja A, Singer M, Markowska M, Zakszewski C, Mamidi RN, McMillia M, Han C, Zhou H, Silva J. Dallas S, et al. Among authors: silva j. Curr Drug Metab. 2012 Sep 1;13(7):923-9. doi: 10.2174/138920012802138589. Curr Drug Metab. 2012. PMID: 22475265

6

Bio-generation of stable isotope labeled internal standards for absolute and relative quantitation of drug metabolites in plasma samples by LC-MS/MS.

Li P, Gong Y, Lim HK, Jian W, Edom RW, Salter R, Silva J, Weng N. Li P, et al. Among authors: silva j. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 May 1;926:92-100. doi: 10.1016/j.jchromb.2013.03.006. Epub 2013 Mar 16. J Chromatogr B Analyt Technol Biomed Life Sci. 2013. PMID: 23562907

7

Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans.

Mamidi RN, Cuyckens F, Chen J, Scheers E, Kalamaridis D, Lin R, Silva J, Sha S, Evans DC, Kelley MF, Devineni D, Johnson MD, Lim HK. Mamidi RN, et al. Among authors: silva j. Drug Metab Dispos. 2014 May;42(5):903-16. doi: 10.1124/dmd.113.056440. Epub 2014 Feb 25. Drug Metab Dispos. 2014. PMID: 24568888 Clinical Trial.

8

A nonradioactive approach to investigate the metabolism of therapeutic peptides by tagging with 127i and using inductively-coupled plasma mass spectrometry analysis.

Lim HK, Cao Y, Qiu X, Silva J, Evans DC. Lim HK, et al. Among authors: silva j. Drug Metab Dispos. 2015 Jan;43(1):17-26. doi: 10.1124/dmd.114.059774. Epub 2014 Oct 14. Drug Metab Dispos. 2015. PMID: 25315343

9

Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters.

Chow EC, Wang JZ, Quach HP, Tang H, Evans DC, Li AP, Silva J, Pang KS. Chow EC, et al. Among authors: silva j. Drug Metab Dispos. 2016 Sep;44(9):1524-35. doi: 10.1124/dmd.116.070060. Epub 2016 Jun 24. Drug Metab Dispos. 2016. PMID: 27342868

10

Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.

Chow EC, Quach HP, Zhang Y, Wang JZ, Evans DC, Li AP, Silva J, Tirona RG, Lai Y, Pang KS. Chow EC, et al. Among authors: silva j. J Pharmacol Exp Ther. 2017 Jan;360(1):174-191. doi: 10.1124/jpet.116.236935. Epub 2016 Oct 27. J Pharmacol Exp Ther. 2017. PMID: 27789682

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