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Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity.
Pacheco JDS, Costa DS, Cunha-Júnior EF, Andrade-Neto VV, Fairlamb AH, Wyllie S, Goulart MOF, Santos DC, Silva TL, Alves MA, Costa PRR, Dias AG, Torres-Santos EC. Pacheco JDS, et al. Among authors: silva tl. ACS Med Chem Lett. 2021 Aug 16;12(9):1405-1412. doi: 10.1021/acsmedchemlett.1c00193. eCollection 2021 Sep 9. ACS Med Chem Lett. 2021. PMID: 34531949 Free PMC article.
Rhodium-catalyzed C-H bond activation for the synthesis of quinonoid compounds: Significant Anti-Trypanosoma cruzi activities and electrochemical studies of functionalized quinones.
Jardim GAM, Silva TL, Goulart MOF, de Simone CA, Barbosa JMC, Salomão K, de Castro SL, Bower JF, da Silva Júnior EN. Jardim GAM, et al. Among authors: silva tl. Eur J Med Chem. 2017 Aug 18;136:406-419. doi: 10.1016/j.ejmech.2017.05.011. Epub 2017 May 4. Eur J Med Chem. 2017. PMID: 28521262
Evaluation of naphthoquinones identified the acetylated isolapachol as a potent and selective antiplasmodium agent.
Moreira DR, de Sá MS, Macedo TS, Menezes MN, Reys JR, Santana AE, Silva TL, Maia GL, Barbosa-Filho JM, Camara CA, da Silva TM, da Silva KN, Guimaraes ET, dos Santos RR, Goulart MO, Soares MB. Moreira DR, et al. Among authors: silva tl. J Enzyme Inhib Med Chem. 2015;30(4):615-21. doi: 10.3109/14756366.2014.958083. Epub 2014 Nov 28. J Enzyme Inhib Med Chem. 2015. PMID: 25431148
Mitochondrial disfunction and ROS production are essential for anti-Trypanosoma cruzi activity of β-lapachone-derived naphthoimidazoles.
Bombaça ACS, Viana PG, Santos ACC, Silva TL, Rodrigues ABM, Guimarães ACR, Goulart MOF, da Silva Júnior EN, Menna-Barreto RFS. Bombaça ACS, et al. Among authors: silva tl. Free Radic Biol Med. 2019 Jan;130:408-418. doi: 10.1016/j.freeradbiomed.2018.11.012. Epub 2018 Nov 14. Free Radic Biol Med. 2019. PMID: 30445126
Naphthoquinone-based Hydrazone Hybrids: Synthesis and Potent Activity Against Cancer Cell Lines.
Guimaráes DG, de Assis Gonsalves A, Rolim LA, Araújo EC, Dos Anjos Santos VL, Silva MFS, de Cássia Evangelista de Oliveira F, da Costa MP, Pessoa C, Fonseca Goulart MO, Silva TL, Santos DC, Araújo CRM. Guimaráes DG, et al. Among authors: silva mfs, silva tl. Med Chem. 2021;17(9):945-955. doi: 10.2174/1573406416666200817164308. Med Chem. 2021. PMID: 32807066
Novel fluorescent lapachone-based BODIPY: synthesis, computational and electrochemical aspects, and subcellular localisation of a potent antitumour hybrid quinone.
Gontijo TB, de Freitas RP, de Lima GF, de Rezende LC, Pedrosa LF, Silva TL, F Goulart MO, Cavalcanti BC, Pessoa C, Bruno MP, Corrêa JR, Emery FS, da Silva Júnior EN. Gontijo TB, et al. Among authors: silva tl. Chem Commun (Camb). 2016 Nov 3;52(90):13281-13284. doi: 10.1039/c6cc07054j. Chem Commun (Camb). 2016. PMID: 27775736
192 results