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A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.
Nat Med. 2018 Jul;24(7):1005-1014. doi: 10.1038/s41591-018-0070-2. Epub 2018 Jun 25.
Nat Med. 2018.
PMID: 29942088
Free PMC article.
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes.
Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, Ribas A, Bluestone JA, Garcia KC.
Sockolosky JT, et al. Among authors: silveria sl.
Science. 2018 Mar 2;359(6379):1037-1042. doi: 10.1126/science.aar3246.
Science. 2018.
PMID: 29496879
Free PMC article.
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Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity.
Wang D, Quiros J, Mahuron K, Pai CC, Ranzani V, Young A, Silveria S, Harwin T, Abnousian A, Pagani M, Rosenblum MD, Van Gool F, Fong L, Bluestone JA, DuPage M.
Wang D, et al.
Cell Rep. 2018 Jun 12;23(11):3262-3274. doi: 10.1016/j.celrep.2018.05.050.
Cell Rep. 2018.
PMID: 29898397
Free PMC article.
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Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy.
Spangler JB, Trotta E, Tomala J, Peck A, Young TA, Savvides CS, Silveria S, Votavova P, Salafsky J, Pande VS, Kovar M, Bluestone JA, Garcia KC.
Spangler JB, et al.
J Immunol. 2018 Oct 1;201(7):2094-2106. doi: 10.4049/jimmunol.1800578. Epub 2018 Aug 13.
J Immunol. 2018.
PMID: 30104245
Free PMC article.
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Separating the Good from the Bad: Tumor-Infiltrating Tregs Have Increased Fucosylation.
Silveria S, DuPage M.
Silveria S, et al.
Cancer Immunol Res. 2023 Dec 1;11(12):1570. doi: 10.1158/2326-6066.CIR-23-0857.
Cancer Immunol Res. 2023.
PMID: 37966514
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