Silverman AP - Search Results

1

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.

Liao F, Li A, Xiong M, Bien-Ly N, Jiang H, Zhang Y, Finn MB, Hoyle R, Keyser J, Lefton KB, Robinson GO, Serrano JR, Silverman AP, Guo JL, Getz J, Henne K, Leyns CE, Gallardo G, Ulrich JD, Sullivan PM, Lerner EP, Hudry E, Sweeney ZK, Dennis MS, Hyman BT, Watts RJ, Holtzman DM. Liao F, et al. Among authors: silverman ap. J Clin Invest. 2018 May 1;128(5):2144-2155. doi: 10.1172/JCI96429. Epub 2018 Mar 30. J Clin Invest. 2018. PMID: 29600961 Free PMC article.

2

APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function.

Xiong M, Jiang H, Serrano JR, Gonzales ER, Wang C, Gratuze M, Hoyle R, Bien-Ly N, Silverman AP, Sullivan PM, Watts RJ, Ulrich JD, Zipfel GJ, Holtzman DM. Xiong M, et al. Among authors: silverman ap. Sci Transl Med. 2021 Feb 17;13(581):eabd7522. doi: 10.1126/scitranslmed.abd7522. Sci Transl Med. 2021. PMID: 33597265 Free PMC article.

3

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice.

Ullman JC, Arguello A, Getz JA, Bhalla A, Mahon CS, Wang J, Giese T, Bedard C, Kim DJ, Blumenfeld JR, Liang N, Ravi R, Nugent AA, Davis SS, Ha C, Duque J, Tran HL, Wells RC, Lianoglou S, Daryani VM, Kwan W, Solanoy H, Nguyen H, Earr T, Dugas JC, Tuck MD, Harvey JL, Reyzer ML, Caprioli RM, Hall S, Poda S, Sanchez PE, Dennis MS, Gunasekaran K, Srivastava A, Sandmann T, Henne KR, Thorne RG, Di Paolo G, Astarita G, Diaz D, Silverman AP, Watts RJ, Sweeney ZK, Kariolis MS, Henry AG. Ullman JC, et al. Among authors: silverman ap. Sci Transl Med. 2020 May 27;12(545):eaay1163. doi: 10.1126/scitranslmed.aay1163. Sci Transl Med. 2020. PMID: 32461331

4

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.

Kariolis MS, Wells RC, Getz JA, Kwan W, Mahon CS, Tong R, Kim DJ, Srivastava A, Bedard C, Henne KR, Giese T, Assimon VA, Chen X, Zhang Y, Solanoy H, Jenkins K, Sanchez PE, Kane L, Miyamoto T, Chew KS, Pizzo ME, Liang N, Calvert MEK, DeVos SL, Baskaran S, Hall S, Sweeney ZK, Thorne RG, Watts RJ, Dennis MS, Silverman AP, Zuchero YJY. Kariolis MS, et al. Among authors: silverman ap. Sci Transl Med. 2020 May 27;12(545):eaay1359. doi: 10.1126/scitranslmed.aay1359. Sci Transl Med. 2020. PMID: 32461332

5

Cystine-knot peptides engineered with specificities for α(IIb)β(3) or α(IIb)β(3) and α(v)β(3) integrins are potent inhibitors of platelet aggregation.

Silverman AP, Kariolis MS, Cochran JR. Silverman AP, et al. J Mol Recognit. 2011 Jan-Feb;24(1):127-35. doi: 10.1002/jmr.1036. J Mol Recognit. 2011. PMID: 21194123

6

Engineered ligand-based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis.

Kapur S, Silverman AP, Ye AZ, Papo N, Jindal D, Blumenkranz MS, Cochran JR. Kapur S, et al. Among authors: silverman ap. Bioeng Transl Med. 2017 Mar;2(1):81-91. doi: 10.1002/btm2.10051. Epub 2017 Feb 17. Bioeng Transl Med. 2017. PMID: 28516164 Free PMC article.

7

Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities.

Silverman AP, Levin AM, Lahti JL, Cochran JR. Silverman AP, et al. J Mol Biol. 2009 Jan 30;385(4):1064-75. doi: 10.1016/j.jmb.2008.11.004. Epub 2008 Nov 12. J Mol Biol. 2009. PMID: 19038268 Free PMC article.

8

Interrogating and predicting tolerated sequence diversity in protein folds: application to E. elaterium trypsin inhibitor-II cystine-knot miniprotein.

Lahti JL, Silverman AP, Cochran JR. Lahti JL, et al. Among authors: silverman ap. PLoS Comput Biol. 2009 Sep;5(9):e1000499. doi: 10.1371/journal.pcbi.1000499. Epub 2009 Sep 4. PLoS Comput Biol. 2009. PMID: 19730675 Free PMC article.

9

Evaluation of a (64)Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing alphavbeta3 integrin.

Jiang L, Kimura RH, Miao Z, Silverman AP, Ren G, Liu H, Li P, Gambhir SS, Cochran JR, Cheng Z. Jiang L, et al. Among authors: silverman ap. J Nucl Med. 2010 Feb;51(2):251-258. doi: 10.2967/jnumed.109.069831. J Nucl Med. 2010. PMID: 20124048 Free PMC article.

10

Antagonistic VEGF variants engineered to simultaneously bind to and inhibit VEGFR2 and alphavbeta3 integrin.

Papo N, Silverman AP, Lahti JL, Cochran JR. Papo N, et al. Among authors: silverman ap. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14067-72. doi: 10.1073/pnas.1016635108. Epub 2011 Aug 8. Proc Natl Acad Sci U S A. 2011. PMID: 21825147 Free PMC article.

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