Silverman GA - Search Results

1

Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency.

Cummings EE, O'Reilly LP, King DE, Silverman RM, Miedel MT, Luke CJ, Perlmutter DH, Silverman GA, Pak SC. Cummings EE, et al. Among authors: silverman ga, silverman rm. PLoS One. 2015 Oct 29;10(10):e0141542. doi: 10.1371/journal.pone.0141542. eCollection 2015. PLoS One. 2015. PMID: 26512890 Free PMC article.

2

Development of specific monoclonal antibodies and a sensitive discriminatory immunoassay for the circulating tumor markers SCCA1 and SCCA2.

Cataltepe S, Schick C, Luke CJ, Pak SC, Goldfarb D, Chen P, Tanasiyevic MJ, Posner MR, Silverman GA. Cataltepe S, et al. Among authors: silverman ga. Clin Chim Acta. 2000 May;295(1-2):107-27. doi: 10.1016/s0009-8981(00)00197-2. Clin Chim Acta. 2000. PMID: 10767398

3

Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage.

Luke C, Schick C, Tsu C, Whisstock JC, Irving JA, Brömme D, Juliano L, Shi GP, Chapman HA, Silverman GA. Luke C, et al. Among authors: silverman ga. Biochemistry. 2000 Jun 20;39(24):7081-91. doi: 10.1021/bi000050g. Biochemistry. 2000. PMID: 10852705

4

Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.

Uemura Y, Pak SC, Luke C, Cataltepe S, Tsu C, Schick C, Kamachi Y, Pomeroy SL, Perlmutter DH, Silverman GA. Uemura Y, et al. Among authors: silverman ga. Int J Cancer. 2000 Jul 20;89(4):368-77. doi: 10.1002/1097-0215(20000720)89:4<368::aid-ijc9>3.0.co;2-6. Int J Cancer. 2000. PMID: 10956412 Free article.

5

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature.

Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC. Silverman GA, et al. J Biol Chem. 2001 Sep 7;276(36):33293-6. doi: 10.1074/jbc.R100016200. Epub 2001 Jul 2. J Biol Chem. 2001. PMID: 11435447 Free article. Review. No abstract available.

6

SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases.

Askew YS, Pak SC, Luke CJ, Askew DJ, Cataltepe S, Mills DR, Kato H, Lehoczky J, Dewar K, Birren B, Silverman GA. Askew YS, et al. Among authors: silverman ga. J Biol Chem. 2001 Dec 28;276(52):49320-30. doi: 10.1074/jbc.M108879200. Epub 2001 Oct 16. J Biol Chem. 2001. PMID: 11604408 Free article.

7

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.

Al-Khunaizi M, Luke CJ, Askew YS, Pak SC, Askew DJ, Cataltepe S, Miller D, Mills DR, Tsu C, Brömme D, Irving JA, Whisstock JC, Silverman GA. Al-Khunaizi M, et al. Among authors: silverman ga. Biochemistry. 2002 Mar 5;41(9):3189-99. doi: 10.1021/bi015999x. Biochemistry. 2002. PMID: 11863458

8

SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins.

Pak SC, Kumar V, Tsu C, Luke CJ, Askew YS, Askew DJ, Mills DR, Brömme D, Silverman GA. Pak SC, et al. Among authors: silverman ga. J Biol Chem. 2004 Apr 9;279(15):15448-59. doi: 10.1074/jbc.M400261200. Epub 2004 Jan 22. J Biol Chem. 2004. PMID: 14739286 Free article.

9

Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.

Silverman GA, Whisstock JC, Askew DJ, Pak SC, Luke CJ, Cataltepe S, Irving JA, Bird PI. Silverman GA, et al. Cell Mol Life Sci. 2004 Feb;61(3):301-25. doi: 10.1007/s00018-003-3240-3. Cell Mol Life Sci. 2004. PMID: 14770295 Review.

10

The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases.

Askew DJ, Askew YS, Kato Y, Luke CJ, Pak SC, Brömme D, Silverman GA. Askew DJ, et al. Among authors: silverman ga. Genomics. 2004 Jul;84(1):166-75. doi: 10.1016/j.ygeno.2004.01.014. Genomics. 2004. PMID: 15203214

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