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Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.
Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WHW, DiDonato JA, Brown JM, Lusis AJ, Hazen SL. Zhu W, et al. Among authors: Silverstein RL. Cell. 2016 Mar 24;165(1):111-124. doi: 10.1016/j.cell.2016.02.011. Epub 2016 Mar 10. Cell. 2016. PMID: 26972052 Free PMC article.
Thymidine phosphorylase participates in platelet signaling and promotes thrombosis.
Li W, Gigante A, Perez-Perez MJ, Yue H, Hirano M, McIntyre TM, Silverstein RL. Li W, et al. Among authors: Silverstein RL. Circ Res. 2014 Dec 5;115(12):997-1006. doi: 10.1161/CIRCRESAHA.115.304591. Epub 2014 Oct 6. Circ Res. 2014. PMID: 25287063 Free PMC article.
Platelet metabolism meets thrombosis.
Chen Y, Silverstein RL. Chen Y, et al. Among authors: Silverstein RL. Blood. 2018 Sep 13;132(11):1089-1091. doi: 10.1182/blood-2018-08-865600. Blood. 2018. PMID: 30213838 No abstract available.
Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo.
Yang M, Kholmukhamedov A, Schulte ML, Cooley BC, Scoggins NO, Wood JP, Cameron SJ, Morrell CN, Jobe SM, Silverstein RL. Yang M, et al. Among authors: Silverstein RL. Blood Adv. 2018 Nov 13;2(21):2848-2861. doi: 10.1182/bloodadvances.2018025411. Blood Adv. 2018. PMID: 30381401 Free PMC article.
Disabling the platelet's brakes to promote thrombosis.
Silverstein RL. Silverstein RL. Blood. 2015 Apr 23;125(17):2591-3. doi: 10.1182/blood-2015-03-630822. Blood. 2015. PMID: 25907902
Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis.
Wang Y, Fang C, Gao H, Bilodeau ML, Zhang Z, Croce K, Liu S, Morooka T, Sakuma M, Nakajima K, Yoneda S, Shi C, Zidar D, Andre P, Stephens G, Silverstein RL, Hogg N, Schmaier AH, Simon DI. Wang Y, et al. Among authors: Silverstein RL. J Clin Invest. 2014 May;124(5):2160-71. doi: 10.1172/JCI70966. Epub 2014 Apr 1. J Clin Invest. 2014. PMID: 24691441 Free PMC article. Clinical Trial.
Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria.
Jankowska AM, Szpurka H, Calabro M, Mohan S, Schade AE, Clemente M, Silverstein RL, Maciejewski JP. Jankowska AM, et al. Among authors: Silverstein RL. Haematologica. 2011 Jul;96(7):954-62. doi: 10.3324/haematol.2010.029298. Epub 2011 May 5. Haematologica. 2011. PMID: 21546506 Free PMC article.
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