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Arylamine N-acetyltransferases--from drug metabolism and pharmacogenetics to identification of novel targets for pharmacological intervention.

Sim E, Fakis G, Laurieri N, Boukouvala S. Sim E, et al. Adv Pharmacol. 2012;63:169-205. doi: 10.1016/B978-0-12-398339-8.00005-7. Adv Pharmacol. 2012. PMID: 22776642 Review.

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Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.

Ryan A, Polycarpou E, Lack NA, Evangelopoulos D, Sieg C, Halman A, Bhakta S, Eleftheriadou O, McHugh TD, Keany S, Lowe ED, Ballet R, Abuhammad A, Jacobs WR Jr, Ciulli A, Sim E. Ryan A, et al. Among authors: sim e. Br J Pharmacol. 2017 Jul;174(14):2209-2224. doi: 10.1111/bph.13810. Epub 2017 May 9. Br J Pharmacol. 2017. PMID: 28380256 Free PMC article.

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Exploration of piperidinols as potential antitubercular agents.

Abuhammad A, Fullam E, Bhakta S, Russell AJ, Morris GM, Finn PW, Sim E. Abuhammad A, et al. Among authors: sim e. Molecules. 2014 Oct 10;19(10):16274-90. doi: 10.3390/molecules191016274. Molecules. 2014. PMID: 25310152 Free PMC article.

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Arylamine N-acetyltransferases in mycobacteria.

Sim E, Sandy J, Evangelopoulos D, Fullam E, Bhakta S, Westwood I, Krylova A, Lack N, Noble M. Sim E, et al. Curr Drug Metab. 2008 Jul;9(6):510-9. doi: 10.2174/138920008784892100. Curr Drug Metab. 2008. PMID: 18680471 Free PMC article. Review.

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Homologues of xenobiotic metabolizing N-acetyltransferases in plant-associated fungi: Novel functions for an old enzyme family.

Karagianni EP, Kontomina E, Davis B, Kotseli B, Tsirka T, Garefalaki V, Sim E, Glenn AE, Boukouvala S. Karagianni EP, et al. Among authors: sim e. Sci Rep. 2015 Aug 6;5:12900. doi: 10.1038/srep12900. Sci Rep. 2015. PMID: 26245863 Free PMC article.

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Identification of novel members of the bacterial azoreductase family in Pseudomonas aeruginosa.

Crescente V, Holland SM, Kashyap S, Polycarpou E, Sim E, Ryan A. Crescente V, et al. Among authors: sim e. Biochem J. 2016 Mar 1;473(5):549-58. doi: 10.1042/BJ20150856. Epub 2015 Nov 30. Biochem J. 2016. PMID: 26621870

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From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2.

Laurieri N, Dairou J, Egleton JE, Stanley LA, Russell AJ, Dupret JM, Sim E, Rodrigues-Lima F. Laurieri N, et al. Among authors: sim e. PLoS One. 2014 May 13;9(5):e96370. doi: 10.1371/journal.pone.0096370. eCollection 2014. PLoS One. 2014. PMID: 24823794 Free PMC article.

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N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice.

Loehle JA, Cornish V, Wakefield L, Doll MA, Neale JR, Zang Y, Sim E, Hein DW. Loehle JA, et al. Among authors: sim e. J Pharmacol Exp Ther. 2006 Nov;319(2):724-8. doi: 10.1124/jpet.106.108662. Epub 2006 Jul 20. J Pharmacol Exp Ther. 2006. PMID: 16857729 Free article.

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Insight into the structure of Mesorhizobium loti arylamine N-acetyltransferase 2 (MLNAT2): a biochemical and computational study.

Dairou J, Flatters D, Chaffotte AF, Pluvinage B, Sim E, Dupret JM, Rodrigues-Lima F. Dairou J, et al. Among authors: sim e. FEBS Lett. 2006 Mar 20;580(7):1780-8. doi: 10.1016/j.febslet.2006.02.033. Epub 2006 Feb 24. FEBS Lett. 2006. PMID: 16513121 Free article.

., Dairou, J., Sandy, J., Rodrigues-Lima, F., Dupret, J.M., Noble, M.E.M. and Sim, E. (2005) Structure of Mesorhizobium loti arylamine N-acetyltransferase 1. ...

., Dairou, J., Sandy, J., Rodrigues-Lima, F., Dupret, J.M., Noble, M.E.M. and Sim, E. (2005) Structure of Mesorhizobium …

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Structure and transcriptional regulation of the Nat2 gene encoding for the drug-metabolizing enzyme arylamine N-acetyltransferase type 2 in mice.

Boukouvala S, Price N, Plant KE, Sim E. Boukouvala S, et al. Among authors: sim e. Biochem J. 2003 Nov 1;375(Pt 3):593-602. doi: 10.1042/BJ20030812. Biochem J. 2003. PMID: 12904181 Free PMC article.

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