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Placental expression of arylamine N-acetyltransferases: evidence for linkage disequilibrium between NAT1*10 and NAT2*4 alleles of the two human arylamine N-acetyltransferase loci NAT1 and NAT2.
Smelt VA, Mardon HJ, Sim E. Smelt VA, et al. Among authors: sim e. Pharmacol Toxicol. 1998 Oct;83(4):149-57. doi: 10.1111/j.1600-0773.1998.tb01461.x. Pharmacol Toxicol. 1998. PMID: 9820875
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.
Ryan A, Polycarpou E, Lack NA, Evangelopoulos D, Sieg C, Halman A, Bhakta S, Eleftheriadou O, McHugh TD, Keany S, Lowe ED, Ballet R, Abuhammad A, Jacobs WR Jr, Ciulli A, Sim E. Ryan A, et al. Among authors: sim e. Br J Pharmacol. 2017 Jul;174(14):2209-2224. doi: 10.1111/bph.13810. Epub 2017 May 9. Br J Pharmacol. 2017. PMID: 28380256 Free PMC article.
Exploration of piperidinols as potential antitubercular agents.
Abuhammad A, Fullam E, Bhakta S, Russell AJ, Morris GM, Finn PW, Sim E. Abuhammad A, et al. Among authors: sim e. Molecules. 2014 Oct 10;19(10):16274-90. doi: 10.3390/molecules191016274. Molecules. 2014. PMID: 25310152 Free PMC article.
Arylamine N-acetyltransferases in mycobacteria.
Sim E, Sandy J, Evangelopoulos D, Fullam E, Bhakta S, Westwood I, Krylova A, Lack N, Noble M. Sim E, et al. Curr Drug Metab. 2008 Jul;9(6):510-9. doi: 10.2174/138920008784892100. Curr Drug Metab. 2008. PMID: 18680471 Free PMC article. Review.
Homologues of xenobiotic metabolizing N-acetyltransferases in plant-associated fungi: Novel functions for an old enzyme family.
Karagianni EP, Kontomina E, Davis B, Kotseli B, Tsirka T, Garefalaki V, Sim E, Glenn AE, Boukouvala S. Karagianni EP, et al. Among authors: sim e. Sci Rep. 2015 Aug 6;5:12900. doi: 10.1038/srep12900. Sci Rep. 2015. PMID: 26245863 Free PMC article.
From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2.
Laurieri N, Dairou J, Egleton JE, Stanley LA, Russell AJ, Dupret JM, Sim E, Rodrigues-Lima F. Laurieri N, et al. Among authors: sim e. PLoS One. 2014 May 13;9(5):e96370. doi: 10.1371/journal.pone.0096370. eCollection 2014. PLoS One. 2014. PMID: 24823794 Free PMC article.
N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice.
Loehle JA, Cornish V, Wakefield L, Doll MA, Neale JR, Zang Y, Sim E, Hein DW. Loehle JA, et al. Among authors: sim e. J Pharmacol Exp Ther. 2006 Nov;319(2):724-8. doi: 10.1124/jpet.106.108662. Epub 2006 Jul 20. J Pharmacol Exp Ther. 2006. PMID: 16857729
Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1.
Wang H, Vath GM, Kawamura A, Bates CA, Sim E, Hanna PE, Wagner CR. Wang H, et al. Among authors: sim e. Protein J. 2005 Feb;24(2):65-77. doi: 10.1007/s10930-004-1513-9. Protein J. 2005. PMID: 16003948
Skeletal muscles express the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase.
Rodrigues-Lima F, Cooper RN, Goudeau B, Atmane N, Chamagne AM, Butler-Browne G, Sim E, Vicart P, Dupret JM. Rodrigues-Lima F, et al. Among authors: sim e. J Histochem Cytochem. 2003 Jun;51(6):789-96. doi: 10.1177/002215540305100610. J Histochem Cytochem. 2003. PMID: 12754290
Structure and transcriptional regulation of the Nat2 gene encoding for the drug-metabolizing enzyme arylamine N-acetyltransferase type 2 in mice.
Boukouvala S, Price N, Plant KE, Sim E. Boukouvala S, et al. Among authors: sim e. Biochem J. 2003 Nov 1;375(Pt 3):593-602. doi: 10.1042/BJ20030812. Biochem J. 2003. PMID: 12904181 Free PMC article.
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