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Expression pattern of two otx genes suggests a role in specifying anterior body structures in zebrafish.
Mercier P, Simeone A, Cotelli F, Boncinelli E. Mercier P, et al. Int J Dev Biol. 1995 Aug;39(4):559-73. Int J Dev Biol. 1995. PMID: 8619954
We isolated two zebrafish sequences containing a homeobox related to orthodenticle (otd), a gene expressed in the developing head of Drosophila. One of these is clearly homologous to Otx1, a homeobox gene previously reported to be expressed in the developing …
We isolated two zebrafish sequences containing a homeobox related to orthodenticle (otd), a gene expressed in the developing h …
Xrx1, a novel Xenopus homeobox gene expressed during eye and pineal gland development.
Casarosa S, Andreazzoli M, Simeone A, Barsacchi G. Casarosa S, et al. Mech Dev. 1997 Jan;61(1-2):187-98. doi: 10.1016/s0925-4773(96)00640-5. Mech Dev. 1997. PMID: 9076688
We have isolated a novel Xenopus homeobox gene, Xrx1, belonging to the paired-like class of homeobox genes. Xrx1 is expressed in the anterior neural plate, and subsequently in the neural structures of the developing eye (neural retina and pigmented epithelium), and in othe …
We have isolated a novel Xenopus homeobox gene, Xrx1, belonging to the paired-like class of homeobox genes. Xrx1 is expressed in the …
TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation.
Zannini M, Avantaggiato V, Biffali E, Arnone MI, Sato K, Pischetola M, Taylor BA, Phillips SJ, Simeone A, Di Lauro R. Zannini M, et al. EMBO J. 1997 Jun 2;16(11):3185-97. doi: 10.1093/emboj/16.11.3185. EMBO J. 1997. PMID: 9214635 Free PMC article.
We report in this paper the cloning of TTF-2, a DNA binding protein that recognizes sites on both Tg and TPO promoters. TTF-2 is a new forkhead domain-containing protein whose expression is restricted to the endodermal lining of the foregut and to the ectoderm that …
We report in this paper the cloning of TTF-2, a DNA binding protein that recognizes sites on both Tg and TPO promoters. TTF-2 is a
Developmental expression of the RET protooncogene.
Avantaggiato V, Dathan NA, Grieco M, Fabien N, Lazzaro D, Fusco A, Simeone A, Santoro M. Avantaggiato V, et al. Cell Growth Differ. 1994 Mar;5(3):305-11. Cell Growth Differ. 1994. PMID: 8018563
The RET protooncogene encodes a transmembrane protein of the receptor-type tyrosine kinase family whose ligand has not yet been identified. ...In conclusion, its expression in the early stages of embryogenesis suggests that RET may play a role in the differentiation …
The RET protooncogene encodes a transmembrane protein of the receptor-type tyrosine kinase family whose ligand has not yet been ident …
Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes.
Buanne P, Incerti B, Guardavaccaro D, Avvantaggiato V, Simeone A, Tirone F. Buanne P, et al. Genomics. 1998 Jul 15;51(2):233-42. doi: 10.1006/geno.1998.5260. Genomics. 1998. PMID: 9722946
The rat PC4 gene had been initially isolated as a nerve growth factor-inducible sequence in PC12 cells. Although its function remains unknown, recently it has been shown that PC4 is necessary to muscle differentiation and that it might have a role in signal transduc …
The rat PC4 gene had been initially isolated as a nerve growth factor-inducible sequence in PC12 cells. Although its function remains …
Differential DNA binding properties of three human homeodomain proteins.
Corsetti MT, Briata P, Sanseverino L, Daga A, Airoldi I, Simeone A, Palmisano G, Angelini C, Boncinelli E, Corte G. Corsetti MT, et al. Nucleic Acids Res. 1992 Sep 11;20(17):4465-72. doi: 10.1093/nar/20.17.4465. Nucleic Acids Res. 1992. PMID: 1357628 Free PMC article.
The three HOX proteins bind to a DNA sequence known to be a target site for Antennapedia protein with a very similar affinity (Kd = 1-2 x 10(-9) M). ...HOX 2C, 3C and 4B behaved quite differently, showing low affinity for promoters of genes located upstream f …
The three HOX proteins bind to a DNA sequence known to be a target site for Antennapedia protein with a very similar af …
Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation.
Acampora D, Mazan S, Lallemand Y, Avantaggiato V, Maury M, Simeone A, Brûlet P. Acampora D, et al. Development. 1995 Oct;121(10):3279-90. Development. 1995. PMID: 7588062
We have replaced part of the mouse homeogene Otx2 coding region with the E. coli lacZ coding sequence, thus creating a null allele of Otx2. ...In gastrulating heterozygous embryos, a post-transcriptional repression acts on lacZ transcripts in the ectoderm, but not i …
We have replaced part of the mouse homeogene Otx2 coding region with the E. coli lacZ coding sequence, thus creating a null allele of …
Human HOX genes are differentially activated by retinoic acid in embryonal carcinoma cells according to their position within the four loci.
Stornaiuolo A, Acampora D, Pannese M, D'Esposito M, Morelli F, Migliaccio E, Rambaldi M, Faiella A, Nigro V, Simeone A, et al. Stornaiuolo A, et al. Cell Differ Dev. 1990 Aug;31(2):119-27. doi: 10.1016/0922-3371(90)90015-o. Cell Differ Dev. 1990. PMID: 1977502
Human homoeobox-containing genes in development.
Acampora D, Pannese M, D'Esposito M, Simeone A, Boncinelli E. Acampora D, et al. Hum Reprod. 1987 Jul;2(5):407-14. doi: 10.1093/oxfordjournals.humrep.a136559. Hum Reprod. 1987. PMID: 2888786
The homoeobox is a 183-bp DNA sequence conserved in several Drosophila genes controlling segmentation and segment identity. Homoeobox sequences have been detected in the genome of species ranging from insects and annelids to vertebrates, and homoeobox-containing genes have …
The homoeobox is a 183-bp DNA sequence conserved in several Drosophila genes controlling segmentation and segment identity. Homoeobox …
Expression of the neuron-specific FE65 gene marks the development of embryo ganglionic derivatives.
Simeone A, Duilio A, Fiore F, Acampora D, De Felice C, Faraonio R, Paolocci F, Cimino F, Russo T. Simeone A, et al. Dev Neurosci. 1994;16(1-2):53-60. doi: 10.1159/000112088. Dev Neurosci. 1994. PMID: 7867517
The major transcript of the FE65 gene is a neuron-specific mRNA that encodes a nuclear protein whose aminoterminal domain strongly activates the transcription of a reporter gene when fused to a heterologous DNA-binding domain. ...Thus FE65 gene express …
The major transcript of the FE65 gene is a neuron-specific mRNA that encodes a nuclear protein whose aminoterminal domain stro …
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