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The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release.
Brain O, Owens BM, Pichulik T, Allan P, Khatamzas E, Leslie A, Steevels T, Sharma S, Mayer A, Catuneanu AM, Morton V, Sun MY, Jewell D, Coccia M, Harrison O, Maloy K, Schönefeldt S, Bornschein S, Liston A, Simmons A. Brain O, et al. Among authors: simmons a. Immunity. 2013 Sep 19;39(3):521-36. doi: 10.1016/j.immuni.2013.08.035. Immunity. 2013. PMID: 24054330 Free article.
NOD2-mediated autophagy and Crohn disease.
Brain O, Allan P, Simmons A. Brain O, et al. Among authors: simmons a. Autophagy. 2010 Apr;6(3):412-4. doi: 10.4161/auto.6.3.11389. Epub 2010 Apr 3. Autophagy. 2010. PMID: 20212355
The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate.
Ranasinghe SR, Kramer HB, Wright C, Kessler BM, di Gleria K, Zhang Y, Gillespie GM, Blais ME, Culshaw A, Pichulik T, Simmons A, Rowland-Jones SL, McMichael AJ, Dong T. Ranasinghe SR, et al. Among authors: simmons a. PLoS Pathog. 2011 May;7(5):e1001341. doi: 10.1371/journal.ppat.1001341. Epub 2011 May 12. PLoS Pathog. 2011. PMID: 21589893 Free PMC article.
RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events.
Colak E, Leslie A, Zausmer K, Khatamzas E, Kubarenko AV, Pichulik T, Klimosch SN, Mayer A, Siggs O, Hector A, Fischer R, Klesser B, Rautanen A, Frank M, Hill AV, Manoury B, Beutler B, Hartl D, Simmons A, Weber AN. Colak E, et al. Among authors: simmons a. J Immunol. 2014 Jun 15;192(12):5963-73. doi: 10.4049/jimmunol.1303058. Epub 2014 May 9. J Immunol. 2014. PMID: 24813206 Free PMC article.
1,357 results