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Yeast as a model system for anticancer drug discovery.
Simon JA, Bedalov A. Simon JA, et al. Nat Rev Cancer. 2004 Jun;4(6):481-92. doi: 10.1038/nrc1372. Nat Rev Cancer. 2004. PMID: 15170450 Review. No abstract available.
Thymidine incorporation is highly predictive of colony formation and can be used for high-throughput screening.
Lamb JR, Goehle S, Ludlow C, Simon JA. Lamb JR, et al. Among authors: simon ja. Biotechniques. 2001 May;30(5):1118-20, 1122, 1124. doi: 10.2144/01305dd04. Biotechniques. 2001. PMID: 11355347
The predicted beta12-beta13 loop is important for inhibition of PP2Acalpha by the antitumor drug fostriecin.
Evans DR, Simon JA. Evans DR, et al. Among authors: simon ja. FEBS Lett. 2001 Jun 1;498(1):110-5. doi: 10.1016/s0014-5793(01)02448-6. FEBS Lett. 2001. PMID: 11389908
Cell-based assays for identification of novel double-strand break-inducing agents.
Dunstan HM, Ludlow C, Goehle S, Cronk M, Szankasi P, Evans DR, Simon JA, Lamb JR. Dunstan HM, et al. Among authors: simon ja. J Natl Cancer Inst. 2002 Jan 16;94(2):88-94. doi: 10.1093/jnci/94.2.88. J Natl Cancer Inst. 2002. PMID: 11792746
Novel approaches to screen for anticancer drugs using Saccharomyces cerevisiae.
Simon JA, Yen TJ. Simon JA, et al. Methods Mol Biol. 2003;223:555-76. doi: 10.1385/1-59259-329-1:555. Methods Mol Biol. 2003. PMID: 12777751 Review. No abstract available.
Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast.
Hirao M, Posakony J, Nelson M, Hruby H, Jung M, Simon JA, Bedalov A. Hirao M, et al. Among authors: simon ja. J Biol Chem. 2003 Dec 26;278(52):52773-82. doi: 10.1074/jbc.M308966200. Epub 2003 Oct 8. J Biol Chem. 2003. PMID: 14534292
., and Simon, J. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 15113-15118). We have now defined a critical amino acid residue within a small helical module of Hst1 that confers relative resistance to splitomicin. ...
., and Simon, J. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 15113-15118). We have now defined a critical amino acid residue within …
Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma.
Bonham M, Posakony J, Coleman I, Montgomery B, Simon J, Nelson PS. Bonham M, et al. Among authors: simon j. Clin Cancer Res. 2005 May 15;11(10):3905-14. doi: 10.1158/1078-0432.CCR-04-1974. Clin Cancer Res. 2005. PMID: 15897592
Yeast as a model system for anticancer drug discovery.
Simon JA. Simon JA. Expert Opin Ther Targets. 2001 Apr;5(2):177-95. doi: 10.1517/14728222.5.2.177. Expert Opin Ther Targets. 2001. PMID: 15992175
[Chemistry and biology of NAD-dependent deacetylases].
Simon JA, Hirao M. Simon JA, et al. Tanpakushitsu Kakusan Koso. 2005 Aug;50(9):1049-55. Tanpakushitsu Kakusan Koso. 2005. PMID: 16083042 Review. Japanese. No abstract available.
Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.
Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A. Gatbonton T, et al. Among authors: simon ja. PLoS Genet. 2006 Mar;2(3):e35. doi: 10.1371/journal.pgen.0020035. Epub 2006 Mar 17. PLoS Genet. 2006. PMID: 16552446 Free PMC article.
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