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Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis: The HYPRESS Randomized Clinical Trial.
Keh D, Trips E, Marx G, Wirtz SP, Abduljawwad E, Bercker S, Bogatsch H, Briegel J, Engel C, Gerlach H, Goldmann A, Kuhn SO, Hüter L, Meier-Hellmann A, Nierhaus A, Kluge S, Lehmke J, Loeffler M, Oppert M, Resener K, Schädler D, Schuerholz T, Simon P, Weiler N, Weyland A, Reinhart K, Brunkhorst FM; SepNet–Critical Care Trials Group. Keh D, et al. Among authors: Simon P. JAMA. 2016 Nov 1;316(17):1775-1785. doi: 10.1001/jama.2016.14799. JAMA. 2016. PMID: 27695824 Clinical Trial.
Septic shock occurred in 36 of 170 patients (21.2%) in the hydrocortisone group and 39 of 170 patients (22.9%) in the placebo group (difference, -1.8%; 95% CI, -10.7% to 7.2%; P = .70). No significant differences were observed between the hydrocortisone and placebo groups for time until septic shock; mortality in the intensive care unit or in the hospital; or mortality at 28 days (15 of 171 patients [8.8%] vs 14 of 170 patients [8.2%], respectively; difference, 0.5%; 95% CI, -5.6% to 6.7%; P = .86), 90 days (34 of 171 patients [19.9%] vs 28 of 168 patients [16.7%]; difference, 3.2%; 95% CI, -5.1% to 11.4%; P = .44), and 180 days (45 of 168 patients [26.8%] vs 37 of 167 patients [22.2%], respectively; difference, 4.6%; 95% CI, -4.6% to 13.7%; P = .32). ...
Septic shock occurred in 36 of 170 patients (21.2%) in the hydrocortisone group and 39 of 170 patients (22.9%) in the placebo group (differe …
Two strategies for prevention of cytomegalovirus infections after liver transplantation.
Simon P, Sasse M, Laudi S, Petroff D, Bartels M, Kaisers UX, Bercker S. Simon P, et al. World J Gastroenterol. 2016 Mar 28;22(12):3412-7. doi: 10.3748/wjg.v22.i12.3412. World J Gastroenterol. 2016. PMID: 27022223 Free PMC article.
The difference in overall mortality was not significant, nor was it significant for one-year mortality where it was 10% (95%CI: 8%-28%, P = 0.31) higher for the preemptive group. ...Patients who were treated according to the preemptive algorithm had a significantly higher rate risk of therapeutic intervention with ganciclovir [n = 16 (23.5%) vs n = 3 (4.9%), P = 0.003)]. ...
The difference in overall mortality was not significant, nor was it significant for one-year mortality where it was 10% (95%CI: 8%-28%, P
Treatment of MRSA pneumonia: Clinical and economic comparison of linezolid vs. vancomycin - a retrospective analysis of medical charts and re-imbursement data of real-life patient populations.
Wilke MH, Becker K, Kloss S, Heimann SM, Goldmann A, Weber B, Pletz MW, Simon P, Petrik C. Wilke MH, et al. Among authors: Simon P. GMS Infect Dis. 2017 Jan 27;5:Doc02. doi: 10.3205/id000028. eCollection 2017. GMS Infect Dis. 2017. PMID: 30671324 Free PMC article.
All-cause in-hospital mortality was also lower in patients receiving linezolid (22 patients [23.2%] vs. 54 patients [41.2%]) (logistic regression analysis; odds ratio linezolid/vancomycin: 0.351; 95% CI: 0.184-0.671; p<0.01). The analysis of the total costs of stay in ICU did not reveal any major differences between the two treatment groups (cost ratio linezolid/vancomycin: 1.29; 95% CI: 0.84-1.98; p=0.24). ...
All-cause in-hospital mortality was also lower in patients receiving linezolid (22 patients [23.2%] vs. 54 patients [41.2%]) (logistic regre …
Inflammatory response is no different in children randomized to laparoscopic or open appendectomy.
Simon P, Burkhardt U, Sack U, Kaisers UX, Muensterer OJ. Simon P, et al. J Laparoendosc Adv Surg Tech A. 2009 Apr;19 Suppl 1:S71-6. doi: 10.1089/lap.2008.0155.supp. J Laparoendosc Adv Surg Tech A. 2009. PMID: 18999981 Clinical Trial.
P 0.05 was considered statistically significant. RESULTS: A total of 47 patients with appendicitis were recruited and randomized. ...Average postoperative length of stay without any complications was 6.2 +/-2.5 days in the open group and 4.3 +/- 1.1 days in the laparoscopic group (P 0.01). ...
P 0.05 was considered statistically significant. RESULTS: A total of 47 patients with appendicitis were recruited and randomized. ...
Plasma and tissue pharmacokinetics of fosfomycin in morbidly obese and non-obese surgical patients: a controlled clinical trial.
Dorn C, Petroff D, Neumann N, Kratzer A, El-Najjar N, Dietrich A, Kloft C, Zeitlinger M, Kees MG, Kees F, Wrigge H, Simon P. Dorn C, et al. Among authors: Simon P. J Antimicrob Chemother. 2019 Aug 1;74(8):2335-2340. doi: 10.1093/jac/dkz203. J Antimicrob Chemother. 2019. PMID: 31086958
The pharmacokinetics of fosfomycin in obese versus non-obese patients were characterized by lower peak plasma concentrations (468 ± 139 versus 594 ± 149 mg/L, P = 0.040) and higher V (24.4 ± 6.4 versus 19.0 ± 3.1 L, P = 0.010). ...The drug exposure in tissue was nearly halved in obese compared with non-obese patients (AUC∞ 1052 ± 394 versus 1929 ± 725 mg·h/L, P = 0.0010). ...
The pharmacokinetics of fosfomycin in obese versus non-obese patients were characterized by lower peak plasma concentrations (468 ± 139 vers …
Measurement of soft tissue drug concentrations in morbidly obese and non-obese patients - A prospective, parallel group, open-labeled, controlled, phase IV, single center clinical trial.
Simon P, Petroff D, Dorn C, Ehmann L, Kloft C, Prettin C, Dietrich A, Zeitlinger M, Kees F, Wrigge H. Simon P, et al. Contemp Clin Trials Commun. 2019 May 10;15:100375. doi: 10.1016/j.conctc.2019.100375. eCollection 2019 Sep. Contemp Clin Trials Commun. 2019. PMID: 31193565 Free PMC article.
Lessons learned from excess mortality associated with Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae in liver transplant recipients.
Lübbert C, Rodloff AC, Laudi S, Simon P, Busch T, Mössner J, Bartels M, Kaisers UX. Lübbert C, et al. Among authors: Simon P. Liver Transpl. 2014 Jun;20(6):736-8. doi: 10.1002/lt.23858. Epub 2014 Mar 26. Liver Transpl. 2014. PMID: 24677425 No abstract available.
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