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Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors.
Phisitkul S, Hacker C, Simoni J, Tran RM, Wesson DE. Phisitkul S, et al. Among authors: simoni j. Kidney Int. 2008 Jan;73(2):192-9. doi: 10.1038/sj.ki.5002647. Epub 2007 Oct 31. Kidney Int. 2008. PMID: 17978813
Reduced extracellular pH increases endothelin-1 secretion by human renal microvascular endothelial cells.
Wesson DE, Simoni J, Green DF. Wesson DE, et al. Among authors: simoni j. J Clin Invest. 1998 Feb 1;101(3):578-83. doi: 10.1172/JCI854. J Clin Invest. 1998. PMID: 9449690 Free PMC article.
Nephrotoxicity of hemoglobin solutions.
Feola M, Simoni J, Tran R, Canizaro PC. Feola M, et al. Among authors: simoni j. Biomater Artif Cells Artif Organs. 1990;18(2):233-49. doi: 10.3109/10731199009117304. Biomater Artif Cells Artif Organs. 1990. PMID: 2114937
An improved blood substitute. In vivo evaluation of its renal effects.
Simoni J, Simoni G, Hartsell A, Feola M. Simoni J, et al. Among authors: simoni g. ASAIO J. 1997 Sep-Oct;43(5):M714-25. ASAIO J. 1997. PMID: 9360140
Evidence for the direct inhibition of endothelin-1 secretion by hemoglobin in human endothelial cells.
Simoni J, Simoni G, Lox CD, Prien SD, Shires GT. Simoni J, et al. Among authors: simoni g. ASAIO J. 1995 Jul-Sep;41(3):M641-51. doi: 10.1097/00002480-199507000-00090. ASAIO J. 1995. PMID: 8573884
Dietary protein induces endothelin-mediated kidney injury through enhanced intrinsic acid production.
Wesson DE, Nathan T, Rose T, Simoni J, Tran RM. Wesson DE, et al. Among authors: simoni j. Kidney Int. 2007 Feb;71(3):210-7. doi: 10.1038/sj.ki.5002036. Epub 2006 Dec 13. Kidney Int. 2007. PMID: 17164833
Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia.
Reungjui S, Hu H, Mu W, Roncal CA, Croker BP, Patel JM, Nakagawa T, Srinivas T, Byer K, Simoni J, Wesson D, Sitprija V, Johnson RJ. Reungjui S, et al. Among authors: simoni j. Kidney Int. 2007 Dec;72(12):1483-92. doi: 10.1038/sj.ki.5002564. Epub 2007 Oct 10. Kidney Int. 2007. PMID: 17928827
Continued smoking exacerbates but cessation ameliorates progression of early type 2 diabetic nephropathy.
Phisitkul K, Hegazy K, Chuahirun T, Hudson C, Simoni J, Rajab H, Wesson DE. Phisitkul K, et al. Among authors: simoni j. Am J Med Sci. 2008 Apr;335(4):284-91. doi: 10.1097/MAJ.0b013e318156b799. Am J Med Sci. 2008. PMID: 18414067
Role of free hemoglobin in 8-iso prostaglandin F2-alpha synthesis in chronic renal failure and its impact on CD163-Hb scavenger receptor and on coronary artery endothelium.
Simoni J, Simoni G, Griswold JA, Moeller JF, Tsikouris JP, Khanna A, Roongsritong C, Wesson DE. Simoni J, et al. Among authors: simoni g. ASAIO J. 2006 Nov-Dec;52(6):652-61. doi: 10.1097/01.mat.0000235282.89757.9f. ASAIO J. 2006. PMID: 17117055
Increased endothelin activity mediates augmented distal nephron acidification induced by dietary protein.
Khanna A, Simoni J, Hacker C, Duran MJ, Wesson DE. Khanna A, et al. Among authors: simoni j. Trans Am Clin Climatol Assoc. 2005;116:239-56; discussion 257-8. Trans Am Clin Climatol Assoc. 2005. PMID: 16555618 Free PMC article.
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