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Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet.
Wesson DE, Simoni J. Wesson DE, et al. Among authors: simoni j. Kidney Int. 2010 Dec;78(11):1128-35. doi: 10.1038/ki.2010.348. Epub 2010 Sep 22. Kidney Int. 2010. PMID: 20861823
Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors.
Phisitkul S, Hacker C, Simoni J, Tran RM, Wesson DE. Phisitkul S, et al. Among authors: simoni j. Kidney Int. 2008 Jan;73(2):192-9. doi: 10.1038/sj.ki.5002647. Epub 2007 Oct 31. Kidney Int. 2008. PMID: 17978813
Dietary protein induces endothelin-mediated kidney injury through enhanced intrinsic acid production.
Wesson DE, Nathan T, Rose T, Simoni J, Tran RM. Wesson DE, et al. Among authors: simoni j. Kidney Int. 2007 Feb;71(3):210-7. doi: 10.1038/sj.ki.5002036. Epub 2006 Dec 13. Kidney Int. 2007. PMID: 17164833
Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia.
Reungjui S, Hu H, Mu W, Roncal CA, Croker BP, Patel JM, Nakagawa T, Srinivas T, Byer K, Simoni J, Wesson D, Sitprija V, Johnson RJ. Reungjui S, et al. Among authors: simoni j. Kidney Int. 2007 Dec;72(12):1483-92. doi: 10.1038/sj.ki.5002564. Epub 2007 Oct 10. Kidney Int. 2007. PMID: 17928827
Increased endothelin activity mediates augmented distal nephron acidification induced by dietary protein.
Khanna A, Simoni J, Hacker C, Duran MJ, Wesson DE. Khanna A, et al. Among authors: simoni j. Trans Am Clin Climatol Assoc. 2005;116:239-56; discussion 257-8. Trans Am Clin Climatol Assoc. 2005. PMID: 16555618 Free PMC article.
Cigarette smoking enhances increased urine albumin excretion as a risk factor for glomerular filtration rate decline in primary hypertension.
Warmoth L, Regalado MM, Simoni J, Harrist RB, Wesson DE. Warmoth L, et al. Among authors: simoni j. Am J Med Sci. 2005 Sep;330(3):111-9. doi: 10.1097/00000441-200509000-00003. Am J Med Sci. 2005. PMID: 16174994
Endothelin-induced increased aldosterone activity mediates augmented distal nephron acidification as a result of dietary protein.
Khanna A, Simoni J, Wesson DE. Khanna A, et al. Among authors: simoni j. J Am Soc Nephrol. 2005 Jul;16(7):1929-35. doi: 10.1681/ASN.2004121054. Epub 2005 May 4. J Am Soc Nephrol. 2005. PMID: 15872074
Increased endothelin activity mediates augmented distal nephron acidification induced by dietary protein.
Khanna A, Simoni J, Hacker C, Duran MJ, Wesson DE. Khanna A, et al. Among authors: simoni j. J Am Soc Nephrol. 2004 Sep;15(9):2266-75. doi: 10.1097/01.ASN.0000138233.78329.4E. J Am Soc Nephrol. 2004. PMID: 15339976
Fruit and Vegetable Treatment of Chronic Kidney Disease-Related Metabolic Acidosis Reduces Cardiovascular Risk Better than Sodium Bicarbonate.
Goraya N, Munoz-Maldonado Y, Simoni J, Wesson DE. Goraya N, et al. Among authors: simoni j. Am J Nephrol. 2019;49(6):438-448. doi: 10.1159/000500042. Epub 2019 Apr 17. Am J Nephrol. 2019. PMID: 30995657 Clinical Trial.
Urine citrate excretion as a marker of acid retentionĀ in patients with chronic kidney disease without overt metabolic acidosis.
Goraya N, Simoni J, Sager LN, Madias NE, Wesson DE. Goraya N, et al. Among authors: simoni j. Kidney Int. 2019 May;95(5):1190-1196. doi: 10.1016/j.kint.2018.11.033. Epub 2019 Mar 1. Kidney Int. 2019. PMID: 30846270
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