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Mammalian iron transporters: families SLC11 and SLC40.
Montalbetti N, Simonin A, Kovacs G, Hediger MA. Montalbetti N, et al. Among authors: simonin a. Mol Aspects Med. 2013 Apr-Jun;34(2-3):270-87. doi: 10.1016/j.mam.2013.01.002. Mol Aspects Med. 2013. PMID: 23506870 Review.
SLC11A1 is expressed in the lysosomal compartment of macrophages and in the tertiary granules of neutrophils, playing a key role in innate resistance against infection by intracellular microbes. SLC11A2 is a key player in iron metabolism and is ubiquitously expresse …
SLC11A1 is expressed in the lysosomal compartment of macrophages and in the tertiary granules of neutrophils, playing a key role in i …
The SLC1 high-affinity glutamate and neutral amino acid transporter family.
Kanai Y, Clémençon B, Simonin A, Leuenberger M, Lochner M, Weisstanner M, Hediger MA. Kanai Y, et al. Among authors: simonin a. Mol Aspects Med. 2013 Apr-Jun;34(2-3):108-20. doi: 10.1016/j.mam.2013.01.001. Mol Aspects Med. 2013. PMID: 23506861 Review.
In addition, glutamate transporters play a role in glutamate excitotoxicity following an ischemic stroke, due to reversed glutamate transport. ...Activators of SLC1 family members have also been discovered but there are only a few examples known....
In addition, glutamate transporters play a role in glutamate excitotoxicity following an ischemic stroke, due to reversed glutamate t …
The Hydroxyl Side Chain of a Highly Conserved Serine Residue Is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1/SLC1A2.
Simonin A, Montalbetti N, Gyimesi G, Pujol-Giménez J, Hediger MA. Simonin A, et al. J Biol Chem. 2015 Dec 18;290(51):30464-74. doi: 10.1074/jbc.M115.689836. Epub 2015 Oct 19. J Biol Chem. 2015. PMID: 26483543 Free PMC article.
On the other hand, the threonine mutant, which is a more conservative mutation, exhibited similar substrate selectivity, substrate and sodium affinities as WT but a lower selectivity for Na(+) over Li(+). ...Altogether, our findings confirm a pivotal role of …
On the other hand, the threonine mutant, which is a more conservative mutation, exhibited similar substrate selectivity, substrate an …
Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H+ exchanger 1 ubiquitylation, endocytosis, and function.
Simonin A, Fuster D. Simonin A, et al. J Biol Chem. 2010 Dec 3;285(49):38293-303. doi: 10.1074/jbc.M110.115089. Epub 2010 Sep 20. J Biol Chem. 2010. PMID: 20855896 Free PMC article.
Here, we demonstrate that NHE1 undergoes ubiquitylation at the plasma membrane by a process that is unprecedented for a mammalian ion transport protein. ...Our data suggest a broader role for β-arrestins in the regulation of membrane ion transport proteins th …
Here, we demonstrate that NHE1 undergoes ubiquitylation at the plasma membrane by a process that is unprecedented for a mammal …
Development of the First Fluorescence Screening Assay for the SLC39A2 Zinc Transporter.
Franz MC, Simonin A, Graeter S, Hediger MA, Kovacs G. Franz MC, et al. Among authors: simonin a. J Biomol Screen. 2014 Jul;19(6):909-16. doi: 10.1177/1087057114526781. Epub 2014 Mar 11. J Biomol Screen. 2014. PMID: 24619115
The aim of this study was to develop a screening assay for compound screening targeting hZIP2. Employing the pIRES2-DsRed Express 2 bicistronic vector, we detected human ZIP2 expression at the plasma membrane in transiently transfected HEK293 cells. ...The cadmium influx v …
The aim of this study was to develop a screening assay for compound screening targeting hZIP2. Employing the pIRES2-DsRed Express 2 b …
Development and Validation of a Fast and Homogeneous Cell-Based Fluorescence Screening Assay for Divalent Metal Transporter 1 (DMT1/SLC11A2) Using the FLIPR Tetra.
Montalbetti N, Simonin A, Dalghi MG, Kovacs G, Hediger MA. Montalbetti N, et al. Among authors: simonin a. J Biomol Screen. 2014 Jul;19(6):900-8. doi: 10.1177/1087057114521663. Epub 2014 Feb 6. J Biomol Screen. 2014. PMID: 24505080
In addition, Cd(2+)was used as a substrate for DMT1, and we find a Kivalue of 2.1 µM for a compound (2-(3-carbamimidoylsulfanylmethyl-benzyl)-isothiourea) belonging to the benzylisothioureas family, which has been identified as a DMT1 inhibitor. The op …
In addition, Cd(2+)was used as a substrate for DMT1, and we find a Kivalue of 2.1 µM for a compound (2-(3-carbamimidoyl …
Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity.
Kovacs G, Montalbetti N, Franz MC, Graeter S, Simonin A, Hediger MA. Kovacs G, et al. Among authors: simonin a. Cell Calcium. 2013 Oct;54(4):276-86. doi: 10.1016/j.ceca.2013.07.003. Epub 2013 Aug 20. Cell Calcium. 2013. PMID: 23968883
Inhibition of the human epithelial calcium channel TRPV6 by 2-aminoethoxydiphenyl borate (2-APB).
Kovacs G, Montalbetti N, Simonin A, Danko T, Balazs B, Zsembery A, Hediger MA. Kovacs G, et al. Among authors: simonin a. Cell Calcium. 2012 Dec;52(6):468-80. doi: 10.1016/j.ceca.2012.08.005. Epub 2012 Oct 4. Cell Calcium. 2012. PMID: 23040501
TRPV6, a highly calcium-selective member of the transient receptor potential (TRP) channel superfamily, is a major pathway for calcium absorption in the fetal and adult body. ...In this study, we tested 2-APB, a widely used SOC inhibitor on human TRPV6 (hTRPV …
TRPV6, a highly calcium-selective member of the transient receptor potential (TRP) channel superfamily, is a major pathway for …
Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2.
Montalbetti N, Simonin A, Simonin C, Awale M, Reymond JL, Hediger MA. Montalbetti N, et al. Among authors: simonin a, simonin c. Biochem Pharmacol. 2015 Aug 1;96(3):216-24. doi: 10.1016/j.bcp.2015.05.002. Epub 2015 Jun 3. Biochem Pharmacol. 2015. PMID: 26047847
We discovered a new compound, named pyrimidinone 8, which mediates a reversible linear non-competitive inhibition of human DMT1 (hDMT1) transport activity with a Ki of ∼20μM. ...Pyrimidinone 8 represents a novel versatile tool compound and it may serve …
We discovered a new compound, named pyrimidinone 8, which mediates a reversible linear non-competitive inhibition of human DMT …
Inherited epithelial transporter disorders--an overview.
Bergeron MJ, Simonin A, Bürzle M, Hediger MA. Bergeron MJ, et al. Among authors: simonin a. J Inherit Metab Dis. 2008 Apr;31(2):178-87. doi: 10.1007/s10545-008-0861-6. Epub 2008 Apr 14. J Inherit Metab Dis. 2008. PMID: 18415698 Review.
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