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Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men.
van Raalte DH, van Leeuwen N, Simonis-Bik AM, Nijpels G, van Haeften TW, Schafer SA, Boomsma DI, Kramer MH, J Heine R, Maassen JA, Staiger H, Machicao F, Häring HU, Slagboom PE, Willemsen G, de Geus EJ, Dekker JM, Fritsche A, Eekhoff EM, Diamant M, 't Hart LM. van Raalte DH, et al. Among authors: simonis bik am. Diabet Med. 2012 Aug;29(8):e211-6. doi: 10.1111/j.1464-5491.2012.03690.x. Diabet Med. 2012. PMID: 22507373
Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function.
Simonis-Bik AM, Nijpels G, van Haeften TW, Houwing-Duistermaat JJ, Boomsma DI, Reiling E, van Hove EC, Diamant M, Kramer MH, Heine RJ, Maassen JA, Slagboom PE, Willemsen G, Dekker JM, Eekhoff EM, de Geus EJ, 't Hart LM. Simonis-Bik AM, et al. Diabetes. 2010 Jan;59(1):293-301. doi: 10.2337/db09-1048. Epub 2009 Oct 15. Diabetes. 2010. PMID: 19833888 Free PMC article.
The heritability of beta cell function parameters in a mixed meal test design.
Simonis-Bik AM, Boomsma DI, Dekker JM, Diamant M, de Geus EJ, 't Hart LM, Heine RJ, Kramer MH, Maassen JA, Mari A, Tura A, Willemsen G, Eekhoff EM. Simonis-Bik AM, et al. Diabetologia. 2011 May;54(5):1043-51. doi: 10.1007/s00125-011-2060-5. Epub 2011 Feb 11. Diabetologia. 2011. PMID: 21311857 Free PMC article.
Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.
Guigas B, de Leeuw van Weenen JE, van Leeuwen N, Simonis-Bik AM, van Haeften TW, Nijpels G, Houwing-Duistermaat JJ, Beekman M, Deelen J, Havekes LM, Penninx BW, Vogelzangs N, van 't Riet E, Dehghan A, Hofman A, Witteman JC, Uitterlinden AG, Grarup N, Jørgensen T, Witte DR, Lauritzen T, Hansen T, Pedersen O, Hottenga J, Romijn JA, Diamant M, Kramer MH, Heine RJ, Willemsen G, Dekker JM, Eekhoff EM, Pijl H, de Geus EJ, Slagboom PE, 't Hart LM. Guigas B, et al. Among authors: simonis bik am. Diabet Med. 2014 Aug;31(8):1001-8. doi: 10.1111/dme.12464. Epub 2014 May 2. Diabet Med. 2014. PMID: 24724616
Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps.
't Hart LM, Simonis-Bik AM, Nijpels G, van Haeften TW, Schäfer SA, Houwing-Duistermaat JJ, Boomsma DI, Groenewoud MJ, Reiling E, van Hove EC, Diamant M, Kramer MH, Heine RJ, Maassen JA, Kirchhoff K, Machicao F, Häring HU, Slagboom PE, Willemsen G, Eekhoff EM, de Geus EJ, Dekker JM, Fritsche A. 't Hart LM, et al. Diabetes. 2010 Jan;59(1):287-92. doi: 10.2337/db09-0736. Epub 2009 Oct 6. Diabetes. 2010. PMID: 19808892 Free PMC article.
The impact of genetic variation in the G6PC2 gene on insulin secretion depends on glycemia.
Heni M, Ketterer C, Hart LM, Ranta F, van Haeften TW, Eekhoff EM, Dekker JM, Boomsma DI, Nijpels G, Kramer MH, Diamant M, Simonis-Bik AM, Heine RJ, de Geus EJ, Schäfer SA, Machicao F, Ullrich S, Thamer C, Stefan N, Staiger H, Häring HU, Fritsche A. Heni M, et al. Among authors: simonis bik am. J Clin Endocrinol Metab. 2010 Dec;95(12):E479-84. doi: 10.1210/jc.2010-0860. Epub 2010 Sep 8. J Clin Endocrinol Metab. 2010. PMID: 20826583
Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp.
van Vliet-Ostaptchouk JV, van Haeften TW, Landman GW, Reiling E, Kleefstra N, Bilo HJ, Klungel OH, de Boer A, van Diemen CC, Wijmenga C, Boezen HM, Dekker JM, van 't Riet E, Nijpels G, Welschen LM, Zavrelova H, Bruin EJ, Elbers CC, Bauer F, Onland-Moret NC, van der Schouw YT, Grobbee DE, Spijkerman AM, van der A DL, Simonis-Bik AM, Eekhoff EM, Diamant M, Kramer MH, Boomsma DI, de Geus EJ, Willemsen G, Slagboom PE, Hofker MH, 't Hart LM. van Vliet-Ostaptchouk JV, et al. Among authors: simonis bik am. PLoS One. 2012;7(3):e32148. doi: 10.1371/journal.pone.0032148. Epub 2012 Mar 5. PLoS One. 2012. PMID: 22403629 Free PMC article.
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