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Neurostimulation for abdominal pain-related functional gastrointestinal disorders in adolescents: a randomised, double-blind, sham-controlled trial
Kovacic K, et al. Lancet Gastroenterol Hepatol 2017 - Clinical Trial. Among authors: Simpson P. PMID 28826627
Effects were sustained for an extended period (median follow-up 9·2 weeks [IQR 6·4-13·4]) in the PENFS group: median 8·0 (IQR 7·0-9·0) at baseline to 6·0 (5·0-8·0) at follow-up versus sham: 7·5 (6·0-9·0) at baseline to 7·0 (5·0-8·0) at follow-up (p<0·0001). ...These effects were sustained at extended follow-up in the PENFS group: median 24·5 (IQR 16·8-33·3) at baseline to 12 (3·6-22·5) at follow-up, compared with sham: 22·8 (8·4-38·2) at baseline to 16·8 (4·8-33·6) at follow-up (p=0·018). ...
Effects were sustained for an extended period (median follow-up 9·2 weeks [IQR 6·4-13·4]) in the PENFS group: median 8·0 (IQR 7·0-9·0) at ba …
Children and adolescents with repaired tetralogy of fallot report quality of life similar to healthy peers
Kwon EN, et al. Congenit Heart Dis 2011. Among authors: Simpson PM. PMID 21269409
Compared with peers, self-reported QOL was higher than for chronically ill children (overall QOL 85 vs. 77, P= 0.007) and similar to healthy children (85 vs. 83, P= 0.44), while proxy report by parent was similar to parents of chronically ill children (overall QOL 77 vs. 74, P= 0.035). ...Overall QOL positively correlated with child's VO(2) max% predicted, when reported by child (r = 0.47, P < 0.05) and parent proxy (r = 0.63, P < 0.05). ...
Compared with peers, self-reported QOL was higher than for chronically ill children (overall QOL 85 vs. 77, P= 0.007) and similar to …
Red flags in children with chronic abdominal pain and Crohn's disease-a single center experience
El-Chammas K, et al. J Pediatr 2013. Among authors: Simpson P. PMID 23069193
Patients with functional gastrointestinal disorders had more stressors (P < .001), were more likely to have a positive family history of irritable bowel syndrome, reflux, or constipation (P < .05), were more likely to have vomiting but less likely to have hematochezia, weight loss, and problems gaining weight (P < .05); wake from sleep and joint pain were no different between groups. ...
Patients with functional gastrointestinal disorders had more stressors (P < .001), were more likely to have a positive family hist …
Feeding dysfunction in children with single ventricle following staged palliation
Hill GD, et al. J Pediatr 2014 - Clinical Trial. Among authors: Simpson PM. PMID 24161218 Free PMC article.
Compared with a normal reference population, patients with single ventricle had statistically significant differences in dysfunctional food manipulation (P < .001), mealtime aggression (P = .002), choking/gagging/vomiting (P < .001), resistance to eating (P < .001), and parental aversion to mealtime (P < .001). ...Multivariable analysis identified current gastrostomy tube use (P = .02) and a single parent household (P = .01) as risk factors for feeding dysfunction. ...
Compared with a normal reference population, patients with single ventricle had statistically significant differences in dysfunctional food …
Chronic idiopathic nausea of childhood
Kovacic K, et al. J Pediatr 2014. Among authors: Simpson P. PMID 24607239
Subjects with chronic nausea had a more severe presentation with daily 88% (vs 26%) and constant 60% (vs 10%) nausea (P < .001), one-half with peak morning intensity. In the chronic nausea group, 62% had migraines, and 71% (vs 22%) had familial migraines (P < .001), 36% had postural tachycardia syndrome and 27% cyclic vomiting syndrome. ...

Subjects with chronic nausea had a more severe presentation with daily 88% (vs 26%) and constant 60% (vs 10%) nausea (P < .001), o

Comparison of light and electron microscopy in measurement of esophageal intercellular space in children
Altaf MA, et al. J Pediatr Gastroenterol Nutr 2014. Among authors: Simpson P. PMID 24647333
RESULTS: The median (range) EEIC space measured using EM in the NERD group was 1.15 (0.74-1.64) μm compared with 0.93 (0.67-1.11) μm in the control group (P = 0.002). The median (range) EEIC space measured using LM was 14.4% (9.6%-26.3%) in the NERD group and 9.6% (8.5%-17.2%) in controls (P = 0.003). ...
RESULTS: The median (range) EEIC space measured using EM in the NERD group was 1.15 (0.74-1.64) μm compared with 0.93 (0.67-1.11) μm in the …
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