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Pax6; a pleiotropic player in development.
Simpson TI, Price DJ. Simpson TI, et al. Bioessays. 2002 Nov;24(11):1041-51. doi: 10.1002/bies.10174. Bioessays. 2002. PMID: 12386935 Review.
Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization.
Manuel M, Georgala PA, Carr CB, Chanas S, Kleinjan DA, Martynoga B, Mason JO, Molinek M, Pinson J, Pratt T, Quinn JC, Simpson TI, Tyas DA, van Heyningen V, West JD, Price DJ. Manuel M, et al. Among authors: simpson ti. Development. 2007 Feb;134(3):545-55. doi: 10.1242/dev.02764. Epub 2007 Jan 3. Development. 2007. PMID: 17202185 Free PMC article.
Long-range downstream enhancers are essential for Pax6 expression.
Kleinjan DA, Seawright A, Mella S, Carr CB, Tyas DA, Simpson TI, Mason JO, Price DJ, van Heyningen V. Kleinjan DA, et al. Among authors: simpson ti. Dev Biol. 2006 Nov 15;299(2):563-81. doi: 10.1016/j.ydbio.2006.08.060. Epub 2006 Aug 30. Dev Biol. 2006. PMID: 17014839 Free PMC article.
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