Abstract
The beta-adrenergic agonist isoproterenol and analogs of adenosine 3',5'-monophosphate (cAMP) induced a potassium current, M current, in freshly dissociated gastric smooth muscle cells. Muscarinic agonists suppress this current, apparently by acting at a locus downstream from regulation of cAMP levels by adenylate cyclase and phosphodiesterase. Thus, M current can be induced by an agent and regulated in antagonistic fashion by beta-adrenergic and muscarinic systems.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetylcholine / pharmacology
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Animals
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Bufo marinus
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Cyclic AMP / physiology
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Electric Conductivity
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In Vitro Techniques
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Isoproterenol / pharmacology
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Membrane Potentials / drug effects
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Muscarine / pharmacology
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Muscle, Smooth / physiology*
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Potassium / physiology*
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Receptors, Adrenergic, beta / physiology*
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Receptors, Muscarinic / physiology*
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Stomach / physiology
Substances
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Receptors, Adrenergic, beta
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Receptors, Muscarinic
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Muscarine
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Cyclic AMP
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Isoproterenol
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Acetylcholine
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Potassium