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Therapeutic potential of resveratrol: the in vivo evidence.
Baur JA, Sinclair DA. Baur JA, et al. Nat Rev Drug Discov. 2006 Jun;5(6):493-506. doi: 10.1038/nrd2060. Epub 2006 May 26. Nat Rev Drug Discov. 2006. PMID: 16732220 Review.
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R. Pearson KJ, et al. Cell Metab. 2008 Aug;8(2):157-68. doi: 10.1016/j.cmet.2008.06.011. Epub 2008 Jul 3. Cell Metab. 2008. PMID: 18599363 Free PMC article.
Small-molecule allosteric activators of sirtuins.
Sinclair DA, Guarente L. Sinclair DA, et al. Annu Rev Pharmacol Toxicol. 2014;54:363-80. doi: 10.1146/annurev-pharmtox-010611-134657. Epub 2013 Oct 16. Annu Rev Pharmacol Toxicol. 2014. PMID: 24160699 Free PMC article. Review.
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Milne JC, et al. Nature. 2007 Nov 29;450(7170):712-6. doi: 10.1038/nature06261. Nature. 2007. PMID: 18046409 Free PMC article.
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA. Price NL, et al. Cell Metab. 2012 May 2;15(5):675-90. doi: 10.1016/j.cmet.2012.04.003. Cell Metab. 2012. PMID: 22560220 Free PMC article.
Mammalian sirtuins: biological insights and disease relevance.
Haigis MC, Sinclair DA. Haigis MC, et al. Annu Rev Pathol. 2010;5:253-95. doi: 10.1146/annurev.pathol.4.110807.092250. Annu Rev Pathol. 2010. PMID: 20078221 Free PMC article. Review.
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Howitz KT, et al. Nature. 2003 Sep 11;425(6954):191-6. doi: 10.1038/nature01960. Epub 2003 Aug 24. Nature. 2003. PMID: 12939617
Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy.
Michan S, Juan AM, Hurst CG, Cui Z, Evans LP, Hatton CJ, Pei DT, Ju M, Sinclair DA, Smith LE, Chen J. Michan S, et al. PLoS One. 2014 Jan 8;9(1):e85031. doi: 10.1371/journal.pone.0085031. eCollection 2014. PLoS One. 2014. PMID: 24416337 Free PMC article.
Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice.
Hua J, Guerin KI, Chen J, Michán S, Stahl A, Krah NM, Seaward MR, Dennison RJ, Juan AM, Hatton CJ, Sapieha P, Sinclair DA, Smith LE. Hua J, et al. Invest Ophthalmol Vis Sci. 2011 Apr 25;52(5):2809-16. doi: 10.1167/iovs.10-6496. Print 2011 Apr. Invest Ophthalmol Vis Sci. 2011. PMID: 21282584 Free PMC article.
Design and synthesis of compounds that extend yeast replicative lifespan.
Yang H, Baur JA, Chen A, Miller C, Adams JK, Kisielewski A, Howitz KT, Zipkin RE, Sinclair DA. Yang H, et al. Aging Cell. 2007 Feb;6(1):35-43. doi: 10.1111/j.1474-9726.2006.00259.x. Epub 2006 Dec 5. Aging Cell. 2007. PMID: 17156081 Free PMC article.
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