Sinclair DA - Search Results

1

Extrachromosomal rDNA circles--a cause of aging in yeast.

Sinclair DA, Guarente L. Sinclair DA, et al. Cell. 1997 Dec 26;91(7):1033-42. doi: 10.1016/s0092-8674(00)80493-6. Cell. 1997. PMID: 9428525

2

Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease.

Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, Meeker A, Finegold M, Baur JA, Sahin E. Amano H, et al. Among authors: sinclair da. Cell Metab. 2019 Jun 4;29(6):1274-1290.e9. doi: 10.1016/j.cmet.2019.03.001. Epub 2019 Mar 28. Cell Metab. 2019. PMID: 30930169 Free PMC article.

3

The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet.

Mitchell SJ, Martin-Montalvo A, Mercken EM, Palacios HH, Ward TM, Abulwerdi G, Minor RK, Vlasuk GP, Ellis JL, Sinclair DA, Dawson J, Allison DB, Zhang Y, Becker KG, Bernier M, de Cabo R. Mitchell SJ, et al. Among authors: sinclair da. Cell Rep. 2014 Mar 13;6(5):836-43. doi: 10.1016/j.celrep.2014.01.031. Epub 2014 Feb 27. Cell Rep. 2014. PMID: 24582957 Free PMC article.

4

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Gomes AP, et al. Among authors: sinclair da. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. Cell. 2013. PMID: 24360282 Free PMC article.

5

Studying the replicative life span of yeast cells.

Sinclair DA. Sinclair DA. Methods Mol Biol. 2013;1048:49-63. doi: 10.1007/978-1-62703-556-9_5. Methods Mol Biol. 2013. PMID: 23929097 Free PMC article.

6

Germline energetics, aging, and female infertility.

Tilly JL, Sinclair DA. Tilly JL, et al. Among authors: sinclair da. Cell Metab. 2013 Jun 4;17(6):838-850. doi: 10.1016/j.cmet.2013.05.007. Cell Metab. 2013. PMID: 23747243 Free PMC article. Review.

7

Impairment of an Endothelial NAD⁺-H₂S Signaling Network Is a Reversible Cause of Vascular Aging.

Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Das A, et al. Among authors: sinclair da. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. Cell. 2018. PMID: 29570999 Free PMC article.

8

Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels.

Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA. Anderson RM, et al. Among authors: sinclair da. J Biol Chem. 2002 May 24;277(21):18881-90. doi: 10.1074/jbc.M111773200. Epub 2002 Mar 7. J Biol Chem. 2002. PMID: 11884393

9

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.

Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA. Bitterman KJ, et al. Among authors: sinclair da. J Biol Chem. 2002 Nov 22;277(47):45099-107. doi: 10.1074/jbc.M205670200. Epub 2002 Sep 23. J Biol Chem. 2002. PMID: 12297502

10

The role of protein arginine methylation in the formation of silent chromatin.

Yu MC, Lamming DW, Eskin JA, Sinclair DA, Silver PA. Yu MC, et al. Among authors: sinclair da. Genes Dev. 2006 Dec 1;20(23):3249-54. doi: 10.1101/gad.1495206. Genes Dev. 2006. PMID: 17158743 Free PMC article.

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