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Molecular mechanisms of yeast aging.
Sinclair DA, Mills K, Guarente L. Sinclair DA, et al. Trends Biochem Sci. 1998 Apr;23(4):131-4. doi: 10.1016/s0968-0004(98)01188-8. Trends Biochem Sci. 1998. PMID: 9584615 Review.
Studying the replicative life span of yeast cells.
Sinclair DA. Sinclair DA. Methods Mol Biol. 2013;1048:49-63. doi: 10.1007/978-1-62703-556-9_5. Methods Mol Biol. 2013. PMID: 23929097 Free PMC article.
Here we describe how to calorically restrict yeast cells, the methods used to determine the replicative life span (RLS) of budding yeast cells, how to selectively kill daughter cells using the mother enrichment program (MEP), how to measure recombination frequency at the rDNA loc …
Here we describe how to calorically restrict yeast cells, the methods used to determine the replicative life span (RLS) of budding yeast cel …
Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin.
Bitterman KJ, Medvedik O, Sinclair DA. Bitterman KJ, et al. Microbiol Mol Biol Rev. 2003 Sep;67(3):376-99, table of contents. doi: 10.1128/mmbr.67.3.376-399.2003. Microbiol Mol Biol Rev. 2003. PMID: 12966141 Free PMC article. Review.
Paradigms and pitfalls of yeast longevity research.
Sinclair DA. Sinclair DA. Mech Ageing Dev. 2002 Apr 30;123(8):857-67. doi: 10.1016/s0047-6374(02)00023-4. Mech Ageing Dev. 2002. PMID: 12044934 Review.
Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.
Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Das A, et al. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. Cell. 2018. PMID: 29570999 Free PMC article.
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels.
Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA. Anderson RM, et al. J Biol Chem. 2002 May 24;277(21):18881-90. doi: 10.1074/jbc.M111773200. Epub 2002 Mar 7. J Biol Chem. 2002. PMID: 11884393
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.
Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA. Bitterman KJ, et al. J Biol Chem. 2002 Nov 22;277(47):45099-107. doi: 10.1074/jbc.M205670200. Epub 2002 Sep 23. J Biol Chem. 2002. PMID: 12297502
The role of protein arginine methylation in the formation of silent chromatin.
Yu MC, Lamming DW, Eskin JA, Sinclair DA, Silver PA. Yu MC, et al. Genes Dev. 2006 Dec 1;20(23):3249-54. doi: 10.1101/gad.1495206. Genes Dev. 2006. PMID: 17158743 Free PMC article.
Aging in Saccharomyces cerevisiae.
Sinclair D, Mills K, Guarente L. Sinclair D, et al. Annu Rev Microbiol. 1998;52:533-60. doi: 10.1146/annurev.micro.52.1.533. Annu Rev Microbiol. 1998. PMID: 9891807 Review.
Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae.
Ashrafi K, Sinclair D, Gordon JI, Guarente L. Ashrafi K, et al. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9100-5. doi: 10.1073/pnas.96.16.9100. Proc Natl Acad Sci U S A. 1999. PMID: 10430902 Free PMC article.
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