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Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport.
Bioorg Med Chem. 2010 Nov 1;18(21):7611-20. doi: 10.1016/j.bmc.2010.08.038. Epub 2010 Aug 21.
Bioorg Med Chem. 2010.
PMID: 20869252
Free PMC article.
Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.
Hintersteiner M, Ambrus G, Bednenko J, Schmied M, Knox AJ, Meisner NC, Gstach H, Seifert JM, Singer EL, Gerace L, Auer M.
Hintersteiner M, et al. Among authors: singer el.
ACS Chem Biol. 2010 Oct 15;5(10):967-79. doi: 10.1021/cb100094k.
ACS Chem Biol. 2010.
PMID: 20677820
Free PMC article.
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A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model.
Yant SR, Mulato A, Hansen D, Tse WC, Niedziela-Majka A, Zhang JR, Stepan GJ, Jin D, Wong MH, Perreira JM, Singer E, Papalia GA, Hu EY, Zheng J, Lu B, Schroeder SD, Chou K, Ahmadyar S, Liclican A, Yu H, Novikov N, Paoli E, Gonik D, Ram RR, Hung M, McDougall WM, Brass AL, Sundquist WI, Cihlar T, Link JO.
Yant SR, et al.
Nat Med. 2019 Sep;25(9):1377-1384. doi: 10.1038/s41591-019-0560-x. Epub 2019 Sep 9.
Nat Med. 2019.
PMID: 31501601
Free PMC article.
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Clinical targeting of HIV capsid protein with a long-acting small molecule.
Link JO, Rhee MS, Tse WC, Zheng J, Somoza JR, Rowe W, Begley R, Chiu A, Mulato A, Hansen D, Singer E, Tsai LK, Bam RA, Chou CH, Canales E, Brizgys G, Zhang JR, Li J, Graupe M, Morganelli P, Liu Q, Wu Q, Halcomb RL, Saito RD, Schroeder SD, Lazerwith SE, Bondy S, Jin D, Hung M, Novikov N, Liu X, Villaseñor AG, Cannizzaro CE, Hu EY, Anderson RL, Appleby TC, Lu B, Mwangi J, Liclican A, Niedziela-Majka A, Papalia GA, Wong MH, Leavitt SA, Xu Y, Koditek D, Stepan GJ, Yu H, Pagratis N, Clancy S, Ahmadyar S, Cai TZ, Sellers S, Wolckenhauer SA, Ling J, Callebaut C, Margot N, Ram RR, Liu YP, Hyland R, Sinclair GI, Ruane PJ, Crofoot GE, McDonald CK, Brainard DM, Lad L, Swaminathan S, Sundquist WI, Sakowicz R, Chester AE, Lee WE, Daar ES, Yant SR, Cihlar T.
Link JO, et al.
Nature. 2020 Aug;584(7822):614-618. doi: 10.1038/s41586-020-2443-1. Epub 2020 Jul 1.
Nature. 2020.
PMID: 32612233
Free PMC article.
Clinical Trial.
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Effects of dehydroepiandrosterone and cyano-ketone on ovarian weight, cholesterol content, and ultrastructure in PMS-HCG treated, immature rats.
Singer EL, Seelig LL Jr, Rennels EG.
Singer EL, et al.
Endocrinology. 1971 Nov;89(5):1223-35. doi: 10.1210/endo-89-5-1223.
Endocrinology. 1971.
PMID: 4255462
No abstract available.
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Suppression of adrenal glands by ovarian hormones in gonadotrophin-treated immature rats.
Rennels EG, Singer EL.
Rennels EG, et al. Among authors: singer el.
Tex Rep Biol Med. 1970 Fall;28(3):303-16.
Tex Rep Biol Med. 1970.
PMID: 4330111
No abstract available.
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