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Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials.
Singhal A, Cole TJ, Lucas A. Singhal A, et al. Lancet. 2001 Feb 10;357(9254):413-9. doi: 10.1016/S0140-6736(00)04004-6. Lancet. 2001. PMID: 11273059 Clinical Trial.
We undertook such a study to test the hypothesis that early diet programmes blood pressure in later life in children randomly assigned different diets at birth. ...Our data provide experimental evidence of programming of a cardiovascular risk factor by early diet an …
We undertook such a study to test the hypothesis that early diet programmes blood pressure in later life in children randomly assigne …
Preterm birth, vascular function, and risk factors for atherosclerosis.
Singhal A, Kattenhorn M, Cole TJ, Deanfield J, Lucas A. Singhal A, et al. Lancet. 2001 Oct 6;358(9288):1159-60. doi: 10.1016/S0140-6736(01)06276-6. Lancet. 2001. PMID: 11597675 Clinical Trial.
We have tested the hypothesis that low birthweight as a result of preterm birth is associated with reduced flow-mediated endothelial-dependent vasodilation (FMD), which is an early stage in the development of atherosclerosis. Mean FMD in adolescents born preterm who had …
We have tested the hypothesis that low birthweight as a result of preterm birth is associated with reduced flow-mediated endothelial- …
Optimizing Nutrition in Preterm Low Birth Weight Infants-Consensus Summary.
Kumar RK, Singhal A, Vaidya U, Banerjee S, Anwar F, Rao S. Kumar RK, et al. Among authors: singhal a. Front Nutr. 2017 May 26;4:20. doi: 10.3389/fnut.2017.00020. eCollection 2017. Front Nutr. 2017. PMID: 28603716 Free PMC article. Review.
A group of neonatologists, pediatricians, and nutrition experts convened to discuss and frame evidence-based recommendations for optimizing nutrition in preterm low birth weight (LBW) infants. ...This consensus summary serves as a useful guide to clinicians in addre
A group of neonatologists, pediatricians, and nutrition experts convened to discuss and frame evidence-based recommendations for opti
Early growth and later atherosclerosis.
Singhal A. Singhal A. World Rev Nutr Diet. 2013;106:162-7. doi: 10.1159/000342580. Epub 2013 Feb 11. World Rev Nutr Diet. 2013. PMID: 23428696 Review.
The association between infant growth and these risk factors is strong, consistent, shows a dose-response effect, and is biologically plausible. Moreover, experimental data from prospective randomized controlled trials strongly support a causal link between infant g …
The association between infant growth and these risk factors is strong, consistent, shows a dose-response effect, and is biologically …
Breast Milk Consumption in Preterm Neonates and Cardiac Shape in Adulthood.
Lewandowski AJ, Lamata P, Francis JM, Piechnik SK, Ferreira VM, Boardman H, Neubauer S, Singhal A, Leeson P, Lucas A. Lewandowski AJ, et al. Among authors: singhal a. Pediatrics. 2016 Jul;138(1):e20160050. doi: 10.1542/peds.2016-0050. Epub 2016 Jun 14. Pediatrics. 2016. PMID: 27302980 Free PMC article. Clinical Trial.
METHODS: A total of 926 preterm-born infants originally took part in a randomized controlled trial of postnatal milk-feeding regimens between 1982 and 1985 across 5 different UK centers. ...As a comparison group, we recruited an additional 102 individuals bor …
METHODS: A total of 926 preterm-born infants originally took part in a randomized controlled trial of postnatal milk-feeding r …
Elevated blood pressure in preterm-born offspring associates with a distinct antiangiogenic state and microvascular abnormalities in adult life.
Lewandowski AJ, Davis EF, Yu G, Digby JE, Boardman H, Whitworth P, Singhal A, Lucas A, McCormick K, Shore AC, Leeson P. Lewandowski AJ, et al. Among authors: singhal a. Hypertension. 2015 Mar;65(3):607-14. doi: 10.1161/HYPERTENSIONAHA.114.04662. Epub 2014 Dec 22. Hypertension. 2015. PMID: 25534704
A panel of circulating biomarkers, including soluble endoglin and soluble fms-like tyrosine kinase-1, were compared between groups and related to perinatal history and adult cardiovascular risk. ...There was a specific graded association between soluble endoglin and
A panel of circulating biomarkers, including soluble endoglin and soluble fms-like tyrosine kinase-1, were compared between groups an
Preterm heart in adult life: cardiovascular magnetic resonance reveals distinct differences in left ventricular mass, geometry, and function.
Lewandowski AJ, Augustine D, Lamata P, Davis EF, Lazdam M, Francis J, McCormick K, Wilkinson AR, Singhal A, Lucas A, Smith NP, Neubauer S, Leeson P. Lewandowski AJ, et al. Among authors: singhal a. Circulation. 2013 Jan 15;127(2):197-206. doi: 10.1161/CIRCULATIONAHA.112.126920. Epub 2012 Dec 5. Circulation. 2013. PMID: 23224059 Clinical Trial.
We determined whether preterm birth is associated with a distinct left ventricular structure and function in humans. METHODS AND RESULTS: A total of 234 individuals 20 to 39 years of age underwent cardiovascular magnetic resonance. ...Furthermore, they exhibit a
We determined whether preterm birth is associated with a distinct left ventricular structure and function in humans. METHODS AND RESU …
Impaired endothelial responses in apparently healthy young people associated with subclinical variation in blood pressure and cardiovascular phenotype.
Lazdam M, Lewandowski AJ, Kylintireas I, Cunnington C, Diesch J, Francis J, Trevitt C, Neubauer S, Singhal A, Leeson P. Lazdam M, et al. Among authors: singhal a. Am J Hypertens. 2012 Jan;25(1):46-53. doi: 10.1038/ajh.2011.176. Epub 2011 Oct 6. Am J Hypertens. 2012. PMID: 21976278
BACKGROUND: A phenomenon of endothelial impairment, independent of classical cardiovascular risk factors, has been observed in young people. ...Subjects with the greatest decline in FMD over 10 years had a significant increase in mean arterial pressure but similar c …
BACKGROUND: A phenomenon of endothelial impairment, independent of classical cardiovascular risk factors, has been observed in young …
Elevated blood pressure in offspring born premature to hypertensive pregnancy: is endothelial dysfunction the underlying vascular mechanism?
Lazdam M, de la Horra A, Pitcher A, Mannie Z, Diesch J, Trevitt C, Kylintireas I, Contractor H, Singhal A, Lucas A, Neubauer S, Kharbanda R, Alp N, Kelly B, Leeson P. Lazdam M, et al. Among authors: singhal a. Hypertension. 2010 Jul;56(1):159-65. doi: 10.1161/HYPERTENSIONAHA.110.150235. Epub 2010 May 17. Hypertension. 2010. PMID: 20479334 Clinical Trial.
We carried out a 20-year follow-up study of 71 subjects born preterm, 19 to a hypertensive pregnancy and 52 to a normotensive pregnancy. ...
We carried out a 20-year follow-up study of 71 subjects born preterm, 19 to a hypertensive pregnancy and 52 to a normot …
Suboptimal Micronutrient Intake among Children in Europe.
Kaganov B, Caroli M, Mazur A, Singhal A, Vania A. Kaganov B, et al. Among authors: singhal a. Nutrients. 2015 May 13;7(5):3524-35. doi: 10.3390/nu7053524. Nutrients. 2015. PMID: 25984741 Free PMC article. Review.
Adequate dietary intake of micronutrients is not necessarily achieved even in resource-rich areas of the world wherein overeating is a public health concern. ...
Adequate dietary intake of micronutrients is not necessarily achieved even in resource-rich areas of the world wherein overeating is a
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