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Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correlation with in vivo positive inotropic activity.
Sircar I, Weishaar RE, Kobylarz D, Moos WH, Bristol JA. Sircar I, et al. J Med Chem. 1987 Nov;30(11):1955-62. doi: 10.1021/jm00394a005. J Med Chem. 1987. PMID: 2822926
The inhibitory effects on cardiac type I and type II phosphodiesterase, both of which hydrolyze cyclic AMP as well as cyclic GMP, were minimal. ...
The inhibitory effects on cardiac type I and type II phosphodiesterase, both of which hydrolyze cyclic AMP as well as cyclic GMP, wer …
Identification of novel series of human CCR1 antagonists.
Xie YF, Sircar I, Lake K, Komandla M, Ligsay K, Li J, Xu K, Parise J, Schneider L, Huang D, Liu J, Sakurai N, Barbosa M, Jack R. Xie YF, et al. Among authors: sircar i. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2215-21. doi: 10.1016/j.bmcl.2007.09.068. Epub 2007 Sep 25. Bioorg Med Chem Lett. 2008. PMID: 18329267
Synthesis and structure-activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitors.
Pannala M, Kher S, Wilson N, Gaudette J, Sircar I, Zhang SH, Bakhirev A, Yang G, Yuen P, Gorcsan F, Sakurai N, Barbosa M, Cheng JF. Pannala M, et al. Among authors: sircar i. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5978-82. doi: 10.1016/j.bmcl.2007.07.071. Epub 2007 Aug 21. Bioorg Med Chem Lett. 2007. PMID: 17827009
2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists.
Kher S, Lake K, Sircar I, Pannala M, Bakir F, Zapf J, Xu K, Zhang SH, Liu J, Morera L, Sakurai N, Jack R, Cheng JF. Kher S, et al. Among authors: sircar i. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4442-6. doi: 10.1016/j.bmcl.2007.06.017. Epub 2007 Jun 10. Bioorg Med Chem Lett. 2007. PMID: 17587573
Structure-activity relationships of novel, highly potent, selective, and orally active CCR1 antagonists.
Xie YF, Lake K, Ligsay K, Komandla M, Sircar I, Nagarajan G, Li J, Xu K, Parise J, Schneider L, Huang D, Liu J, Dines K, Sakurai N, Barbosa M, Jack R. Xie YF, et al. Among authors: sircar i. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3367-72. doi: 10.1016/j.bmcl.2007.03.104. Epub 2007 Apr 5. Bioorg Med Chem Lett. 2007. PMID: 17446072
Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist.
Sircar I, Gudmundsson KS, Martin R, Liang J, Nomura S, Jayakumar H, Teegarden BR, Nowlin DM, Cardarelli PM, Mah JR, Connell S, Griffith RC, Lazarides E. Sircar I, et al. Bioorg Med Chem. 2002 Jun;10(6):2051-66. doi: 10.1016/s0968-0896(02)00021-4. Bioorg Med Chem. 2002. PMID: 11937364
Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure.
Bristol JA, Sircar I, Moos WH, Evans DB, Weishaar RE. Bristol JA, et al. J Med Chem. 1984 Sep;27(9):1099-101. doi: 10.1021/jm00375a001. J Med Chem. 1984. PMID: 6471063 No abstract available.
Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H- imidazole-5-carboxylic acid (CI-996).
Sircar I, Hodges JC, Quin J 3rd, Bunker AM, Winters RT, Edmunds JJ, Kostlan CR, Connolly C, Kesten SJ, Hamby JM, et al. Sircar I, et al. J Med Chem. 1993 Aug 6;36(16):2253-65. doi: 10.1021/jm00068a002. J Med Chem. 1993. PMID: 8360871
Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists.
Sircar I, Winters RT, Quin J 3rd, Lu GH, Major TC, Panek RL. Sircar I, et al. J Med Chem. 1993 Jun 11;36(12):1735-45. doi: 10.1021/jm00064a007. J Med Chem. 1993. PMID: 8510101
Derivatives of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists.
Edmunds JJ, Klutchko S, Hamby JM, Bunker AM, Connolly CJ, Winters RT, Quin J 3rd, Sircar I, Hodges JC, Panek RL, et al. Edmunds JJ, et al. J Med Chem. 1995 Sep 15;38(19):3759-71. doi: 10.1021/jm00019a005. J Med Chem. 1995. PMID: 7562906
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