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Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds.
Carrella D, Manni I, Tumaini B, Dattilo R, Papaccio F, Mutarelli M, Sirci F, Amoreo CA, Mottolese M, Iezzi M, Ciolli L, Aria V, Bosotti R, Isacchi A, Loreni F, Bardelli A, Avvedimento VE, di Bernardo D, Cardone L. Carrella D, et al. Among authors: sirci f. Oncotarget. 2016 Sep 13;7(37):58743-58758. doi: 10.18632/oncotarget.11318. Oncotarget. 2016. PMID: 27542212 Free PMC article.
Goblet Cell Hyperplasia Requires High Bicarbonate Transport To Support Mucin Release.
Gorrieri G, Scudieri P, Caci E, Schiavon M, Tomati V, Sirci F, Napolitano F, Carrella D, Gianotti A, Musante I, Favia M, Casavola V, Guerra L, Rea F, Ravazzolo R, Di Bernardo D, Galietta LJ. Gorrieri G, et al. Among authors: sirci f. Sci Rep. 2016 Oct 27;6:36016. doi: 10.1038/srep36016. Sci Rep. 2016. PMID: 27786259 Free PMC article.
Pharmacoproteomics pinpoints HSP70 interaction for correction of the most frequent Wilson disease-causing mutant of ATP7B.
Concilli M, Petruzzelli R, Parisi S, Catalano F, Sirci F, Napolitano F, Renda M, Galietta LJV, Di Bernardo D, Polishchuk RS. Concilli M, et al. Among authors: sirci f. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32453-32463. doi: 10.1073/pnas.2006648117. Epub 2020 Dec 7. Proc Natl Acad Sci U S A. 2020. PMID: 33288711 Free PMC article.
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