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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 2
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1995 2
1996 2
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1998 3
1999 7
2000 9
2001 5
2002 9
2003 13
2004 15
2005 21
2006 20
2007 33
2008 33
2009 46
2010 48
2011 49
2012 41
2013 44
2014 52
2015 50
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732 results

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Page 1
Redox regulation of the immune response.
Morris G, Gevezova M, Sarafian V, Maes M. Morris G, et al. Cell Mol Immunol. 2022 Oct;19(10):1079-1101. doi: 10.1038/s41423-022-00902-0. Epub 2022 Sep 2. Cell Mol Immunol. 2022. PMID: 36056148 Free PMC article. Review.
In conclusion, redox-associated mechanisms modulate metabolic reprogramming of immune cells, macrophage and T helper cell polarization, phagocytosis, production of pro- versus anti-inflammatory cytokines, immune training and tolerance, chemotaxis, pathogen sensing, antiviral …
In conclusion, redox-associated mechanisms modulate metabolic reprogramming of immune cells, macrophage and T helper cell polarization, phag …
Current Perspectives on Letermovir and Maribavir for the Management of Cytomegalovirus Infection in Solid Organ Transplant Recipients.
Razonable RR. Razonable RR. Drug Des Devel Ther. 2024 Sep 6;18:3987-4001. doi: 10.2147/DDDT.S265644. eCollection 2024. Drug Des Devel Ther. 2024. PMID: 39258274 Free PMC article. Review.
For decades, CMV management after transplantation has relied on antiviral drugs that inhibit viral DNA polymerase (ganciclovir, foscarnet, and cidofovir). ...Thus, there is a need for additional antiviral drugs to prevent herpes simplex and other herpes viruses when …
For decades, CMV management after transplantation has relied on antiviral drugs that inhibit viral DNA polymerase (ganciclovir, fosca …
Effect of Sirolimus Exposure on the Need for Preemptive Antiviral Therapy for Cytomeglovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation.
Guglieri-Lopez B, Perez-Pitarch A, Garcia-Cadenas I, Gimenez E, Barba P, Rabella N, Hernandez-Boluda JC, Fox L, Valcarcel D, Esquirol A, Ferriols-Lisart R, Sierra J, Solano C, Navarro D, Martino R, Piñana JL. Guglieri-Lopez B, et al. Biol Blood Marrow Transplant. 2019 May;25(5):1022-1030. doi: 10.1016/j.bbmt.2019.01.012. Epub 2019 Jan 10. Biol Blood Marrow Transplant. 2019. PMID: 30639821 Free article.
The current study evaluates the clinical effect of sirolimus exposure on the occurrence of cytomegalovirus (CMV) DNAemia necessitating preemptive antiviral therapy. ...Moreover, this study presents the first predictive model describing the time to CMV DNAemia necess …
The current study evaluates the clinical effect of sirolimus exposure on the occurrence of cytomegalovirus (CMV) DNAemia necessitatin …
Optimizing the clinical utility of sirolimus-based immunosuppression for kidney transplantation.
Tedesco-Silva H, Del Carmen Rial M, Cruz Santiago J, Mazzali M, Pacheco-Silva A, Torres R. Tedesco-Silva H, et al. Clin Transplant. 2019 Feb;33(2):e13464. doi: 10.1111/ctr.13464. Epub 2019 Jan 2. Clin Transplant. 2019. PMID: 30548896 Review.
Its clinical utility has evolved, over more than 15 years, including de novo sirolimus with and without concomitant CNIs and conversion from CNI-based regimens to sirolimus. Sirolimus-containing regimens are associated with preservation of good renal function …
Its clinical utility has evolved, over more than 15 years, including de novo sirolimus with and without concomitant CNIs and conversi …
Malignancy after transplantation.
Buell JF, Gross TG, Woodle ES. Buell JF, et al. Transplantation. 2005 Oct 15;80(2 Suppl):S254-64. doi: 10.1097/01.tp.0000186382.81130.ba. Transplantation. 2005. PMID: 16251858 Review.
Although calcineurin inhibitors and azathioprine have been linked with posttransplant malignancies, newer agents such as mycophenolate mofetil and sirolimus have not and indeed may have antitumor properties. Long-term data are needed to determine if the use of these …
Although calcineurin inhibitors and azathioprine have been linked with posttransplant malignancies, newer agents such as mycophenolat …
Sirolimus in pediatric renal transplantation.
Kasap B. Kasap B. Pediatr Transplant. 2011 Nov;15(7):673-85. doi: 10.1111/j.1399-3046.2011.01575.x. Pediatr Transplant. 2011. PMID: 22004542 Review.
It has unique pharmacokinetic characteristics concerning dosing intervals and reduction of the dose in combination with other immunosuppressants. SRL also has antineoplastic, antiviral, and antiatherogenic advantages over other immunosuppressive agents. The adverse …
It has unique pharmacokinetic characteristics concerning dosing intervals and reduction of the dose in combination with other immunosuppress …
Sirolimus-associated hepatotoxicity in liver transplantation.
Neff GW, Ruiz P, Madariaga JR, Nishida S, Montalbano M, Meyer D, Levi DM, Tzakis AG, O'Brien CB. Neff GW, et al. Ann Pharmacother. 2004 Oct;38(10):1593-6. doi: 10.1345/aph.1E165. Epub 2004 Aug 24. Ann Pharmacother. 2004. PMID: 15328399
Extracted data included sirolimus serum concentrations, frequency of sirolimus-related adverse effects, drug-related clinical hepatitis, and survival outcomes. ...The time to transaminase increase was a mean of 21 days when sirolimus was added, with resolutio …
Extracted data included sirolimus serum concentrations, frequency of sirolimus-related adverse effects, drug-related clinical …
Host Immunomodulatory Interventions in Severe Influenza.
Hui DSC, Chan KKP. Hui DSC, et al. J Infect Dis. 2025 Oct 17;232(Supplement_3):S262-S272. doi: 10.1093/infdis/jiaf328. J Infect Dis. 2025. PMID: 41102617 Free article. Review.
An open-label randomized controlled trial (RCT) found that a triple combination of oseltamivir, clarithromycin, and naproxen improved outcomes in severe influenza. One RCT has indicated that sirolimus with corticosteroids can expedite liberation from mechanical ventilation …
An open-label randomized controlled trial (RCT) found that a triple combination of oseltamivir, clarithromycin, and naproxen improved outcom …
Antiviral activity of immunosuppressors alone and in combination against human adenovirus and cytomegalovirus.
Carretero-Ledesma M, Aguilar-Guisado M, Berastegui-Cabrera J, Balsera-Manzanero M, Pachón J, Cordero E, Sánchez-Céspedes J. Carretero-Ledesma M, et al. Int J Antimicrob Agents. 2024 May;63(5):107116. doi: 10.1016/j.ijantimicag.2024.107116. Epub 2024 Feb 23. Int J Antimicrob Agents. 2024. PMID: 38401774 Free article.
Cyclophosphamide, tacrolimus, cyclosporine, mycophenolic acid, methotrexate, everolimus and sirolimus presented antiviral activity, with 50% inhibitory concentration (IC(50)) values at low micromolar and sub-micromolar concentrations. ...Additionally, mycophenolic a …
Cyclophosphamide, tacrolimus, cyclosporine, mycophenolic acid, methotrexate, everolimus and sirolimus presented antiviral acti …
732 results