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Facilitation of cognitive functions by a specific alpha2-adrenoceptor antagonist, atipamezole.
Haapalinna A, Sirviö J, Lammintausta R. Haapalinna A, et al. Among authors: sirvio j. Eur J Pharmacol. 1998 Apr 17;347(1):29-40. doi: 10.1016/s0014-2999(98)00077-6. Eur J Pharmacol. 1998. PMID: 9650845
Alpha-adrenoceptor-mediated modulation of 5-HT2 receptor agonist induced impulsive responding in a 5-choice serial reaction time task.
Koskinen T, Haapalinna A, Sirviö J. Koskinen T, et al. Among authors: sirvio j. Pharmacol Toxicol. 2003 May;92(5):214-25. doi: 10.1034/j.1600-0773.2003.920504.x. Pharmacol Toxicol. 2003. PMID: 12753409
Alpha2-adrenergic drug effects on brain monoamines, locomotion, and body temperature are largely abolished in mice lacking the alpha2A-adrenoceptor subtype.
Lähdesmäki J, Sallinen J, MacDonald E, Sirviö J, Scheinin M. Lähdesmäki J, et al. Among authors: sirvio j. Neuropharmacology. 2003 Jun;44(7):882-92. doi: 10.1016/s0028-3908(03)00080-7. Neuropharmacology. 2003. PMID: 12726820
Atipamezole, an alpha2-adrenoceptor antagonist, augments the effects of L-DOPA on evoked dopamine release in rat striatum.
Yavich L, Sirviö J, Haapalinna A, Ylinen A, Männistö PT. Yavich L, et al. Among authors: sirvio j. Eur J Pharmacol. 2003 Feb 21;462(1-3):83-9. doi: 10.1016/s0014-2999(03)01324-4. Eur J Pharmacol. 2003. PMID: 12591099
The alpha2-adrenoceptor antagonist atipamezole reduces the development and expression of d-amphetamine-induced behavioural sensitization.
Juhila J, Haapalinna A, Sirviö J, Sallinen J, Honkanen A, Korpi ER, Scheinin M. Juhila J, et al. Among authors: sirvio j. Naunyn Schmiedebergs Arch Pharmacol. 2003 Mar;367(3):274-80. doi: 10.1007/s00210-003-0695-6. Epub 2003 Feb 14. Naunyn Schmiedebergs Arch Pharmacol. 2003. PMID: 12644900
Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective alpha2-adrenoceptor antagonist.
Pertovaara A, Haapalinna A, Sirviö J, Virtanen R. Pertovaara A, et al. Among authors: sirvio j. CNS Drug Rev. 2005 Autumn;11(3):273-88. doi: 10.1111/j.1527-3458.2005.tb00047.x. CNS Drug Rev. 2005. PMID: 16389294 Free PMC article. Review.
Pharmacological characterisation of a structurally novel α2C-adrenoceptor antagonist ORM-10921 and its effects in neuropsychiatric models.
Sallinen J, Holappa J, Koivisto A, Kuokkanen K, Chapman H, Lehtimäki J, Piepponen P, Mijatovic J, Tanila H, Virtanen R, Sirviö J, Haapalinna A. Sallinen J, et al. Among authors: sirvio j. Basic Clin Pharmacol Toxicol. 2013 Oct;113(4):239-49. doi: 10.1111/bcpt.12090. Epub 2013 Jun 20. Basic Clin Pharmacol Toxicol. 2013. PMID: 23718812
Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302.
Sallinen J, Höglund I, Engström M, Lehtimäki J, Virtanen R, Sirviö J, Wurster S, Savola JM, Haapalinna A. Sallinen J, et al. Among authors: sirvio j. Br J Pharmacol. 2007 Feb;150(4):391-402. doi: 10.1038/sj.bjp.0707005. Epub 2007 Jan 15. Br J Pharmacol. 2007. PMID: 17220913 Free PMC article.
Overexpression of alpha2C-adrenoceptors impairs water maze navigation.
Björklund M, Sirviö J, Riekkinen M, Sallinen J, Scheinin M, Riekkinen P Jr. Björklund M, et al. Among authors: sirvio j. Neuroscience. 2000;95(2):481-7. doi: 10.1016/s0306-4522(99)00428-5. Neuroscience. 2000. PMID: 10658628
The effects of a specific alpha(2)-adrenoceptor antagonist, atipamezole, on cognitive performance and brain neurochemistry in aged Fisher 344 rats.
Haapalinna A, Sirviö J, MacDonald E, Virtanen R, Heinonen E. Haapalinna A, et al. Among authors: sirvio j. Eur J Pharmacol. 2000 Jan 10;387(2):141-50. doi: 10.1016/s0014-2999(99)00819-5. Eur J Pharmacol. 2000. PMID: 10650154
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