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Oxidized Lipids in Persistent Pain States.
Osthues T, Sisignano M. Osthues T, et al. Among authors: Sisignano M. Front Pharmacol. 2019 Oct 15;10:1147. doi: 10.3389/fphar.2019.01147. eCollection 2019. Front Pharmacol. 2019. PMID: 31680947 Free PMC article. Review.
Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing.
Brenneis C, Kistner K, Puopolo M, Segal D, Roberson D, Sisignano M, Labocha S, Ferreirós N, Strominger A, Cobos EJ, Ghasemlou N, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. Brenneis C, et al. Among authors: Sisignano M. Version 2. J Neurosci. 2013 Jan 2;33(1):315-26. doi: 10.1523/JNEUROSCI.2804-12.2013. J Neurosci. 2013. PMID: 23283344 Free PMC article.
Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation.
Brenneis C, Sisignano M, Coste O, Altenrath K, Fischer MJ, Angioni C, Fleming I, Brandes RP, Reeh PW, Woolf CJ, Geisslinger G, Scholich K. Brenneis C, et al. Among authors: Sisignano M. Mol Pain. 2011 Oct 4;7:78. doi: 10.1186/1744-8069-7-78. Mol Pain. 2011. PMID: 21970373 Free PMC article.
5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.
Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R, Grant A, Fischer MJ, Schmidtko A, Reeh P, Ji RR, Woolf CJ, Geisslinger G, Scholich K, Brenneis C. Sisignano M, et al. Version 2. J Neurosci. 2012 May 2;32(18):6364-72. doi: 10.1523/JNEUROSCI.5793-11.2012. J Neurosci. 2012. PMID: 22553041 Free PMC article.
The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors.
Coste O, Möser CV, Sisignano M, Kynast KL, Minden A, Geisslinger G, Niederberger E. Coste O, et al. Among authors: Sisignano M. Behav Brain Res. 2012 Sep 1;234(1):121-8. doi: 10.1016/j.bbr.2012.06.017. Epub 2012 Jun 23. Behav Brain Res. 2012. PMID: 22732262
TRP-channels as key integrators of lipid pathways in nociceptive neurons.
Sisignano M, Bennett DL, Geisslinger G, Scholich K. Sisignano M, et al. Prog Lipid Res. 2014 Jan;53:93-107. doi: 10.1016/j.plipres.2013.11.002. Epub 2013 Nov 25. Prog Lipid Res. 2014. PMID: 24287369 Review.
BKCa channels expressed in sensory neurons modulate inflammatory pain in mice.
Lu R, Lukowski R, Sausbier M, Zhang DD, Sisignano M, Schuh CD, Kuner R, Ruth P, Geisslinger G, Schmidtko A. Lu R, et al. Among authors: Sisignano M. Pain. 2014 Mar;155(3):556-65. doi: 10.1016/j.pain.2013.12.005. Epub 2013 Dec 11. Pain. 2014. PMID: 24333777
Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice.
Sisignano M, Angioni C, Ferreiros N, Schuh CD, Suo J, Schreiber Y, Dawes JM, Antunes-Martins A, Bennett DL, McMahon SB, Geisslinger G, Scholich K. Sisignano M, et al. PLoS One. 2013 Dec 9;8(12):e81228. doi: 10.1371/journal.pone.0081228. eCollection 2013. PLoS One. 2013. PMID: 24349046 Free PMC article.
Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity.
Kallenborn-Gerhardt W, Hohmann SW, Syhr KM, Schröder K, Sisignano M, Weigert A, Lorenz JE, Lu R, Brüne B, Brandes RP, Geisslinger G, Schmidtko A. Kallenborn-Gerhardt W, et al. Among authors: Sisignano M. Pain. 2014 Oct;155(10):2161-70. doi: 10.1016/j.pain.2014.08.013. Epub 2014 Aug 17. Pain. 2014. PMID: 25139590
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