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1alpha,25-dihydroxy-24-oxo-16-ene vitamin D3, a metabolite of a synthetic vitamin D3 analog, 1alpha,25-dihydroxy-16-ene vitamin D3, is equipotent to its parent in modulating growth and differentiation of human leukemic cells.
Siu-Caldera ML, Clark JW, Santos-Moore A, Peleg S, Liu YY, Uskoković MR, Sharma S, Reddy GS. Siu-Caldera ML, et al. J Steroid Biochem Mol Biol. 1996 Dec;59(5-6):405-12. doi: 10.1016/s0960-0760(96)00134-3. J Steroid Biochem Mol Biol. 1996. PMID: 9010346
Enhanced biological activity of 1alpha,25-dihydroxy-20-epi-vitamin D3, the C-20 epimer of 1alpha,25-dihydroxyvitamin D3, is in part due to its metabolism into stable intermediary metabolites with significant biological activity.
Siu-Caldera ML, Sekimoto H, Peleg S, Nguyen C, Kissmeyer AM, Binderup L, Weiskopf A, Vouros P, Uskoković MR, Reddy GS. Siu-Caldera ML, et al. J Steroid Biochem Mol Biol. 1999 Dec 15;71(3-4):111-21. doi: 10.1016/s0960-0760(99)00130-2. J Steroid Biochem Mol Biol. 1999. PMID: 10659699
1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3 and 1alpha,25-dihydroxy-16-ene-23-yne-20-epi-vitamin D3: analogs of 1alpha,25-dihydroxyvitamin D3 that resist metabolism through the C-24 oxidation pathway are metabolized through the C-3 epimerization pathway.
Reddy GS, Rao DS, Siu-Caldera ML, Astecker N, Weiskopf A, Vouros P, Sasso GJ, Manchand PS, Uskokovic MR. Reddy GS, et al. Among authors: siu caldera ml. Arch Biochem Biophys. 2000 Nov 15;383(2):197-205. doi: 10.1006/abbi.2000.2074. Arch Biochem Biophys. 2000. PMID: 11185554
Production of 1alpha,25-dihydroxy-3-epi-vitamin D3 in two rat osteosarcoma cell lines (UMR 106 and ROS 17/2.8): existence of the C-3 epimerization pathway in ROS 17/2.8 cells in which the C-24 oxidation pathway is not expressed.
Siu-Caldera ML, Sekimoto H, Weiskopf A, Vouros P, Muralidharan KR, Okamura WH, Bishop J, Norman AW, Uskoković MR, Schuster I, Reddy GS. Siu-Caldera ML, et al. Bone. 1999 May;24(5):457-63. doi: 10.1016/s8756-3282(99)00019-8. Bone. 1999. PMID: 10321905
22 results