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The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat.
Sivarajah A, McDonald MC, Thiemermann C. Sivarajah A, et al. Shock. 2006 Aug;26(2):154-61. doi: 10.1097/01.shk.0000225722.56681.64. Shock. 2006. PMID: 16878023
Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I/R.
Sivarajah A, Collino M, Yasin M, Benetti E, Gallicchio M, Mazzon E, Cuzzocrea S, Fantozzi R, Thiemermann C. Sivarajah A, et al. Shock. 2009 Mar;31(3):267-74. doi: 10.1097/SHK.0b013e318180ff89. Shock. 2009. PMID: 18636044
Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury.
McCormick J, Barry SP, Sivarajah A, Stefanutti G, Townsend PA, Lawrence KM, Eaton S, Knight RA, Thiemermann C, Latchman DS, Stephanou A. McCormick J, et al. Among authors: sivarajah a. FASEB J. 2006 Oct;20(12):2115-7. doi: 10.1096/fj.06-6188fje. Epub 2006 Aug 25. FASEB J. 2006. PMID: 16935931
Inhibitors of calpain activation (PD150606 and E-64) and renal ischemia-reperfusion injury.
Chatterjee PK, Todorovic Z, Sivarajah A, Mota-Filipe H, Brown PA, Stewart KN, Mazzon E, Cuzzocrea S, Thiemermann C. Chatterjee PK, et al. Among authors: sivarajah a. Biochem Pharmacol. 2005 Apr 1;69(7):1121-31. doi: 10.1016/j.bcp.2005.01.003. Biochem Pharmacol. 2005. PMID: 15763548
The cardioprotective effects of preconditioning with endotoxin, but not ischemia, are abolished by a peroxisome proliferator-activated receptor-gamma antagonist.
Sivarajah A, McDonald MC, Thiemermann C. Sivarajah A, et al. J Pharmacol Exp Ther. 2005 May;313(2):896-901. doi: 10.1124/jpet.104.080598. Epub 2005 Feb 25. J Pharmacol Exp Ther. 2005. PMID: 15734901
Beneficial effects of PPAR-gamma ligands in ischemia-reperfusion injury, inflammation and shock.
Abdelrahman M, Sivarajah A, Thiemermann C. Abdelrahman M, et al. Among authors: sivarajah a. Cardiovasc Res. 2005 Mar 1;65(4):772-81. doi: 10.1016/j.cardiores.2004.12.008. Cardiovasc Res. 2005. PMID: 15721857 Review.
Differential effects of caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney.
Chatterjee PK, Todorovic Z, Sivarajah A, Mota-Filipe H, Brown PA, Stewart KN, Cuzzocrea S, Thiemermann C. Chatterjee PK, et al. Among authors: sivarajah a. Eur J Pharmacol. 2004 Oct 25;503(1-3):173-83. doi: 10.1016/j.ejphar.2004.09.025. Eur J Pharmacol. 2004. PMID: 15496312
Overall, these results demonstrate that inhibition of caspase-1 reduces renal ischemia-reperfusion injury to a greater extent than caspase-3 inhibition, supporting the notion that the mode of acute cell death in our model of renal ischemia-reperfusion is primarily via necr …
Overall, these results demonstrate that inhibition of caspase-1 reduces renal ischemia-reperfusion injury to a greater extent than ca …
5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion.
Chatterjee PK, Chatterjee BE, Pedersen H, Sivarajah A, McDonald MC, Mota-Filipe H, Brown PA, Stewart KN, Cuzzocrea S, Threadgill MD, Thiemermann C. Chatterjee PK, et al. Among authors: sivarajah a. Kidney Int. 2004 Feb;65(2):499-509. doi: 10.1111/j.1523-1755.2004.00415.x. Kidney Int. 2004. PMID: 14717920
BACKGROUND: Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme activated by strand breaks in DNA, plays an important role in the development of ischemia/reperfusion (I/R) injury. ...RESULTS: Incubation of proximal tubular cells with H2O2 caused a substantial incr …
BACKGROUND: Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme activated by strand breaks in DNA, plays an important role in the d …
Pyrrolidine dithiocarbamate reduces renal dysfunction and injury caused by ischemia/reperfusion of the rat kidney.
Chatterjee PK, di Villa Bianca RD, Sivarajah A, McDonald MC, Cuzzocrea S, Thiemermann C. Chatterjee PK, et al. Among authors: sivarajah a. Eur J Pharmacol. 2003 Dec 15;482(1-3):271-80. doi: 10.1016/j.ejphar.2003.09.071. Eur J Pharmacol. 2003. PMID: 14660032
Agonists of peroxisome-proliferator activated receptor-gamma reduce renal ischemia/reperfusion injury.
Sivarajah A, Chatterjee PK, Patel NS, Todorovic Z, Hattori Y, Brown PA, Stewart KN, Mota-Filipe H, Cuzzocrea S, Thiemermann C. Sivarajah A, et al. Am J Nephrol. 2003 Jul-Aug;23(4):267-76. doi: 10.1159/000072088. Epub 2003 Jul 3. Am J Nephrol. 2003. PMID: 12840602
Both rosiglitazone and ciglitazone reduced PARP activation indicating a reduction of oxidative stress. CONCLUSION: These results suggest that the PPAR-gamma agonists rosiglitazone and ciglitazone reduce the renal dysfunction and injury associated with I/R of the kidney. We …
Both rosiglitazone and ciglitazone reduced PARP activation indicating a reduction of oxidative stress. CONCLUSION: These results sugg …
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