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Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists.
Cooper M, Llinas A, Hansen P, Caffrey M, Ray A, Sjödin S, Shamovsky I, Wada H, Jellesmark Jensen T, Sivars U, Hultin L, Andersson U, Lundqvist S, Gedda K, Jinton L, Krutrök N, Lewis R, Jansson P, Gardelli C. Cooper M, et al. Among authors: sivars u. J Med Chem. 2020 Sep 10;63(17):9705-9730. doi: 10.1021/acs.jmedchem.0c00828. Epub 2020 Aug 27. J Med Chem. 2020. PMID: 32787075
Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors.
Colley CS, Popovic B, Sridharan S, Debreczeni JE, Hargeaves D, Fung M, An LL, Edwards B, Arnold J, England E, Eghobamien L, Sivars U, Flavell L, Renshaw J, Wickson K, Warrener P, Zha J, Bonnell J, Woods R, Wilkinson T, Dobson C, Vaughan TJ. Colley CS, et al. Among authors: sivars u. MAbs. 2018 Jan;10(1):104-117. doi: 10.1080/19420862.2017.1384892. Epub 2017 Oct 24. MAbs. 2018. PMID: 28952876 Free PMC article.
Identification and Pharmacological Profile of an Indane Based Series of Ghrelin Receptor Full Agonists.
Gardelli C, Wada H, Ray A, Caffrey M, Llinas A, Shamovsky I, Tholander J, Larsson J, Sivars U, Hultin L, Andersson U, Sanganee HJ, Stenvall K, Leidvik B, Gedda K, Jinton L, Rydén Landergren M, Karabelas K. Gardelli C, et al. Among authors: sivars u. J Med Chem. 2018 Jul 26;61(14):5974-5987. doi: 10.1021/acs.jmedchem.8b00322. Epub 2018 Jul 6. J Med Chem. 2018. PMID: 29909635
A MALT1 inhibitor suppresses human myeloid DC, effector T-cell and B-cell responses and retains Th1/regulatory T-cell homeostasis.
Dumont C, Sivars U, Andreasson T, Odqvist L, Mattsson J, DeMicco A, Pardali K, Johansson G, Yrlid L, Cox RJ, Seeliger F, Larsson M, Gehrmann U, Davis AM, Vaarala O. Dumont C, et al. Among authors: sivars u. PLoS One. 2020 Sep 1;15(9):e0222548. doi: 10.1371/journal.pone.0222548. eCollection 2020. PLoS One. 2020. PMID: 32870913 Free PMC article.
18 results